Sensing the local environment: actin architecture and Hippo signalling

被引：129

作者：

Gaspar, Pedro ^{[1
,2
]}

Tapon, Nicolas ^{[1
]}

机构：

[1] Canc Res UK, London Res Inst, Apoptosis & Proliferat Control Lab, London WC2A 3LY, England

[2] Inst Gulbenkian Ciencias, P-2780156 Oeiras, Portugal

来源：

CURRENT OPINION IN CELL BIOLOGY | 2014年 / 31卷

关键词：

MEDIATES CONTACT INHIBITION; WING IMAGINAL DISC; TUMOR-SUPPRESSOR; ALPHA-CATENIN; F-ACTIN; CELL-PROLIFERATION; PLASMA-MEMBRANE; CAPPING PROTEIN; YAP ONCOPROTEIN; TISSUE-GROWTH;

D O I：

10.1016/j.ceb.2014.09.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

The Hippo network is a major conserved growth suppressor pathway that participates in organ size control during development and prevents tumour formation during adult homeostasis. Recent evidence has implicated the actin cytoskeleton as a link between tissue architecture and Hippo signalling. In this review, we will consider the evidence and models proposed for the regulation of Hippo signalling by actin dynamics and structure. We cover aspects of signalling regulation by mechanotransduction, cytoskeletal tethering and the spatial reorganization of signalling components. We also examine the physiological and pathological contexts in which these mechanisms are relevant.

引用

页码：74 / 83

页数：10

共 102 条

[1]

Serum deprivation inhibits the transcriptional co-activator YAP and cell growth via phosphorylation of the 130-kDa isoform of Angiomotin by the LATS1/2 protein kinases [J].

Adler, Jacob J. ;

Johnson, Derrick E. ;

Heller, Brigitte L. ;

Bringman, Lauren R. ;

Ranahan, William P. ;

Conwell, Michael D. ;

Sun, Yang ;

Hudmon, Andy ;

Wells, Clark D. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (43) :17368-17373

[2]

Amot130 Adapts Atrophin-1 Interacting Protein 4 to Inhibit Yes-associated Protein Signaling and Cell Growth [J].

Adler, Jacob J. ;

Heller, Brigitte L. ;

Bringman, Lauren R. ;

Ranahan, William P. ;

Cocklin, Ross R. ;

Goebl, Mark G. ;

Oh, Misook ;

Lim, Hyun-Suk ;

Ingham, Robert J. ;

Wells, Clark D. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 288 (21) :15181-15193

[3]

Model for the regulation of size in the wing imaginal disc of Drosophila [J].

Aegerter-Wilmsen, Tinri ;

Aegerter, Christof M. ;

Hafen, Ernst ;

Basler, Konrad .

MECHANISMS OF DEVELOPMENT, 2007, 124 (04) :318-326

[4]

Integrating force-sensing and signaling pathways in a model for the regulation of wing imaginal disc size [J].

Aegerter-Wilmsen, Tinri ;

Heimlicher, Maria B. ;

Smith, Alister C. ;

de Reuille, Pierre Barbier ;

Smith, Richard S. ;

Aegerter, Christof M. ;

Basler, Konrad .

DEVELOPMENT, 2012, 139 (17) :3221-3231

[5]

Willin/FRMD6 expression activates the Hippo signaling pathway kinases in mammals and antagonizes oncogenic YAP [J].

Angus, L. ;

Moleirinho, S. ;

Herron, L. ;

Sinha, A. ;

Zhang, X. ;

Niestrata, M. ;

Dholakia, K. ;

Prystowsky, M. B. ;

Harvey, K. F. ;

Reynolds, P. A. ;

Gunn-Moore, F. J. .

ONCOGENE, 2012, 31 (02) :238-250

[6]

A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors [J].

Aragona, Mariaceleste ;

Panciera, Tito ;

Manfrin, Andrea ;

Giulitti, Stefano ;

Michielin, Federica ;

Elvassore, Nicola ;

Dupont, Sirio ;

Piccolo, Stefano .

CELL, 2013, 154 (05) :1047-1059

[7]

The FERM-Domain Protein Expanded Regulates Hippo Pathway Activity via Direct Interactions with the Transcriptional Activator Yorkie [J].

Badouel, Caroline ;

Gardano, Laura ;

Amin, Nancy ;

Garg, Ankush ;

Rosenfeld, Robyn ;

Le Bihan, Thierry ;

McNeill, Helen .

DEVELOPMENTAL CELL, 2009, 16 (03) :411-420

[8]

HIGH-FREQUENCY OF INACTIVATING MUTATIONS IN THE NEUROFIBROMATOSIS TYPE-2 GENE (NF2) IN PRIMARY MALIGNANT MESOTHELIOMAS [J].

BIANCHI, AB ;

MITSUNAGA, SI ;

CHENG, JQ ;

KLEIN, WM ;

JHANWAR, SC ;

SEIZINGER, B ;

KLEY, N ;

KLEINSZANTO, AJP ;

TESTA, JR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (24) :10854-10858

[9]

MUTATIONS IN TRANSCRIPT ISOFORMS OF THE NEUROFIBROMATOSIS-2 GENE IN MULTIPLE HUMAN TUMOR TYPES [J].

BIANCHI, AB ;

HARA, T ;

RAMESH, V ;

GAO, JZ ;

KLEINSZANTO, AJP ;

MORIN, F ;

MENON, AG ;

TROFATTER, JA ;

GUSELLA, JF ;

SEIZINGER, BR ;

KLEY, N .

NATURE GENETICS, 1994, 6 (02) :185-192

[10]

An evolutionary shift in the regulation of the Hippo pathway between mice and flies [J].

Bossuyt, W. ;

Chen, C-L ;

Chen, Q. ;

Sudol, M. ;

McNeill, H. ;

Pan, D. ;

Kopp, A. ;

Halder, G. .

ONCOGENE, 2014, 33 (10) :1218-1228

← 1 2 3 4 5 6 7 8 9 10 →