Transcriptional regulation: Kamikaze activators

被引：83

作者：

Thomas, D ^{[1
]}

Tyers, M

机构：

[1] CNRS, Ctr Genet Mol, F-91198 Gif Sur Yvette, France

[2] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Program Mol Biol & Canc, Toronto, ON M5G 1X5, Canada

来源：

CURRENT BIOLOGY | 2000年 / 10卷 / 09期

关键词：

D O I：

10.1016/S0960-9822(00)00462-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transcription factors are often targeted for rapid degradation by the ubiquitin-proteasome system. Recent evidence points to a correlation between the potency and instability of transcriptional activators, suggesting a possible direct role for ubiquitin-dependent proteolysis in transcriptional activation.

引用

页码：R341 / R343

页数：3

共 15 条

[1] REGULATION OF TRANSCRIPTIONAL ELONGATION BY RNA-POLYMERASE-II
BENTLEY, DL
[J]. CURRENT OPINION IN GENETICS & DEVELOPMENT, 1995, 5 (02) : 210 - 216
[2] Cell cycle - Piecing together the p53 puzzle
Carr, AM
[J]. SCIENCE, 2000, 287 (5459) : 1765 - 1766
[3] The ubiquitin system
Hershko, A
Ciechanover, A
[J]. ANNUAL REVIEW OF BIOCHEMISTRY, 1998, 67 : 425 - 479
[4] Ikeda K, 1999, MOL CELL BIOL, V19, P855
[5] Kornberg Roger D., 1999, Trends in Cell Biology, V9, pM46, DOI 10.1016/S0962-8924(99)01679-7
[6] SELECTIVE ARRANGEMENT OF UBIQUITINATED AND D1 PROTEIN-CONTAINING NUCLEOSOMES WITHIN THE DROSOPHILA GENOME
LEVINGER, L
VARSHAVSKY, A
[J]. CELL, 1982, 28 (02) : 375 - 385
[7] Ubiquitination of RNA polymerase II large subunit signaled by phosphorylation of carboxyl-terminal domain
Mitsui, A
Sharp, PA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (11) : 6054 - 6059
[8] Proteasome-mediated degradation of transcriptional activators correlates with activation domain potency in vivo
Molinari, E
Gilman, M
Natesan, S
[J]. EMBO JOURNAL, 1999, 18 (22) : 6439 - 6447
[9] TOM1p, a yeast hect-domain protein which mediates transcriptional regulation through the ADA/SAGA coactivator complexes
Saleh, A
Collart, M
Martens, JA
Genereaux, J
Allard, S
Cote, J
Brandl, CJ
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1998, 282 (05) : 933 - 946
[10] Destruction of Myc by ubiquitin-mediated proteolysis: cancer-associated and transforming mutations stabilize Myc
Salghetti, SE
Kim, SY
Tansey, WP
[J]. EMBO JOURNAL, 1999, 18 (03) : 717 - 726

← 1 2 →