Impact of Extensively Drug-Resistant Tuberculosis on Treatment Outcome of Multidrug-Resistant Tuberculosis Patients with Standardized Regimen: Report from Iran

被引：23

作者：

Tabarsi, Payam ^{[1
]}

Chitsaz, Ehsan ^{[1
]}

Baghaei, Parvaneh ^{[1
]}

Shamaei, Masoud ^{[1
]}

Farnia, Parisa ^{[1
]}

Marjani, Majid ^{[1
]}

Kazempour, Mehdi ^{[1
]}

Amiri, Majid ^{[1
]}

Mansouri, Davood ^{[1
]}

Masjedi, Mohammad R. ^{[1
]}

Velayati, Ali A. ^{[1
]}

Caminero, Jose A. ^{[2
,3
]}

机构：

[1] Shahid Beheshti Univ, Mycobacteriol Res Ctr, NRITLD, Tehran, Iran

[2] Gen Hosp Gran Canaria Dr Negrin, Dept Pneumol, Las Palmas Gran Canaria, Canary Islands, Spain

[3] Int Union TB & Lung Dis, Paris, France

来源：

MICROBIAL DRUG RESISTANCE | 2010年 / 16卷 / 01期

关键词：

XDR TUBERCULOSIS; FOLLOW-UP; MDR-TB; NETHERLANDS; HEALTH; COHORT; PERU;

D O I：

10.1089/mdr.2009.0073

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The limited experience in treating patients with extensively drug-resistant tuberculosis (XDR-TB) shows a therapeutic success rate under 50-60% and there are no publications regarding the outcome of these patients treated with standardized regimens. All multidrug-resistant tuberculosis (MDR-TB) patients hospitalized at the Masih Daneshvari Hospital in Tehran, Iran, during 2004-2007 were recruited. Drug susceptibility testing to 14 drugs (including eight second-line drugs) was performed and a standardized regimen with ofloxacin, cycloserine, prothionamide, and amikacin was administered for all patients. Outcome of the patients was studied, comparing between the MDR-TB non-XDR-TB and the XDR-TB. Fifty-one patients were included, 12 with XDR-TB criteria. Of 51, 48 were HIV negative and HIV status was unknown in three cases. All 12 were HIV negative. XDR-TB infection was significantly associated only with age (p = 0.039). The success rates for the total 51 MDR-TB, the 39 MDR-TB non-XDR-TB, and the 12 XDR-TB patients were 76.5% (39 patients), 87.2% (34 patients), and 41.7% (5 patients), respectively. Resistance to ofloxacin, ciprofloxacin, and amikacin were found to be significantly associated with unsuccessful outcome. In this setting, a standardized second-line drugs regimen produces high treatment success rates in MDR-TB patients unless XDR-TB is present.

引用

页码：81 / 86

页数：6

共 34 条

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[Anonymous], PUBLIC HLTH MYCOBACT

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