Hydrogen-bond lengths in polypeptide helices: No evidence for short hydrogen bonds

被引：24

作者：

Aravinda, S ^{[1
]}

Datta, S

Shamala, N

Balaram, P

机构：

[1] Indian Inst Sci, Mol Biophys Unit, Bangalore 560012, Karnataka, India

[2] Indian Inst Sci, Dept Phys, Bangalore 560012, Karnataka, India

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 48期

关键词：

circular dichroism; helical structures; hydrogen bonds; peptides; structure elucidation;

D O I：

10.1002/anie.200461127

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The long and the short of it: N⋯O distances less than 2.8 Å (see picture) have been implicated in determining the 220 nm circular dichroism band intensity in helical peptides. An analysis of helical peptide crystal structures, however, reveals the average experimentally determined hydrogen-bond lengths are 2.978-3.113 Å (α helix) and 2.907-3.211 Å (3 10 helix).

引用

页码：6728 / 6731

页数：4

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