6-(hydroxyalkyl)penicillanates as probes for mechanisms of β-lactamases

被引：16

作者：

Golemi, D

Maveyraud, L

Ishiwata, A

Tranier, S

Miyashita, K

Nagase, T

Massova, I

Mourey, L

Samama, JP

Mobashery, S ^{[1
]}

机构：

[1] Wayne State Univ, Dept Chem, Detroit, MI 48202 USA

[2] Wayne State Univ, Inst Drug Design, Detroit, MI 48202 USA

[3] CNRS, Inst Pharmacol & Biol Struct, Grp Cristallog Biol, F-31077 Toulouse, France

来源：

JOURNAL OF ANTIBIOTICS | 2000年 / 53卷 / 10期

关键词：

D O I：

10.7164/antibiotics.53.1022

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

6-(Hydroxyalkyl)penicillanates have proven helpful as probes for the me chan isms of beta -lactamases, enzymes of resistance for beta -lactam antibiotics. The present report summarizes the concepts on design, syntheses and use of these molecules in mechanistic studies of beta -lactamases.

引用

页码：1022 / 1027

页数：6

共 19 条

[1]

[Anonymous], 1996, WORLD HLTH REP

[2] Nuances of mechanisms and their implications for evolution of the versatile beta-lactamase activity: From biosynthetic enzymes to drug resistance factors [J].