Molecular organization of an individual Drosophila polytene chromomere:: transcribed sequences in the 10A1-2 band

被引：9

作者：

Kozlova, T

Zhimulev, IF

Kafatos, FC

机构：

[1] European Mol Biol Lab, D-69012 Heidelberg, Germany

[2] Russian Acad Sci, Inst Cytol & Genet, Siberian Div, Novosibirsk 630090, Russia

[3] Harvard Univ, Dept Mol & Cell Biol, Cambridge, MA 02138 USA

来源：

MOLECULAR AND GENERAL GENETICS | 1997年 / 257卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Drosophila; EGF-like repeat; chromomere;

D O I：

10.1007/s004380050623

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Complete cloning of the DNA in the cytogenetic region 9F12-10A7 has allowed us to analyze the fine structure of an individual polytene chromomere in Drosophila melanogaster. In this report we identify the transcriptionally active fragments within the 10A1-2 band. At least 22 DMA fragments representing multiple distinct transcription units are active during embryogenesis, in third-instar larva or in isolated larval tissues. The transcribed fragments are significantly (at least sevenfold) more numerous than the three genetically defined complementation groups in the 10A1-2 band. One of the transcriptionally active zones detected encompasses a previously unsuspected homologue of the genes Delta and Serrate.

引用

页码：55 / 61

页数：7

共 45 条

[1]

ALTSCHUL SF, 1990, J MOL BIOL, V215, P403, DOI 10.1006/jmbi.1990.9999

[2] NOTCH SIGNALING [J].