Activation of human IK and SK Ca2+-activated K+ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime)

被引：158

作者：

Strobæk, D ^{[1
]}

Teuber, L ^{[1
]}

Jorgensen, TD ^{[1
]}

Ahring, PK ^{[1
]}

Kjær, K ^{[1
]}

Hansen, RS ^{[1
]}

Olesen, SP ^{[1
]}

Christophersen, P ^{[1
]}

Skaaning-Jensen, B ^{[1
]}

机构：

[1] NeuroSearch AS, DK-2750 Ballerup, Denmark

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 2004年 / 1665卷 / 1-2期

关键词：

Ca2+ -activated K+ channel; hIK; hSK; 1-EbIO; DC-EBIO; apamin; clotrimazole; whole-cell; HEK293;

D O I：

10.1016/j.bbamem.2004.07.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have identified and characterized the compound NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime) as a potent activator of human Ca2+-activated K+ channels of SK and IK types, whereas it is devoid of effect on BK type channels. IK- and SK-channels have previously been reported to be activated by the benzimidazolinone, 1-EBIO and more potently by its dichloronated-analogue, DC-EBIO. NS309 is at least 1000 times more potent than 1-EBIO and at least 30 times more potent than DC-EBIO when the compounds are compared on the same cell. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：1 / 5

页数：5

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