Chimpanzee adenovirus vaccine generates acute and durable protective immunity against ebolavirus challenge

被引：266

作者：

Stanley, Daphne A. ^{[1
]}

Honko, Anna N. ^{[2
]}

Asiedu, Clement ^{[1
]}

Trefry, John C. ^{[2
]}

Lau-Kilby, Annie W. ^{[1
]}

Johnson, Joshua C. ^{[2
]}

Hensley, Lisa ^{[2
]}

Ammendola, Virginia ^{[3
]}

Abbate, Adele ^{[3
]}

Grazioli, Fabiana ^{[3
]}

Foulds, Kathryn E. ^{[1
]}

Cheng, Cheng ^{[1
]}

Wang, Lingshu ^{[1
]}

Donaldson, Mitzi M. ^{[1
]}

Colloca, Stefano ^{[3
]}

Folgori, Antonella ^{[3
]}

Roederer, Mario ^{[1
]}

Nabel, Gary J. ^{[1
]}

Mascola, John ^{[1
]}

Nicosia, Alfredo ^{[3
,4
,5
]}

Cortese, Riccardo ^{[6
]}

Koup, Richard A. ^{[1
]}

Sullivan, Nancy J. ^{[1
]}

机构：

[1] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA

[2] US Army Med Res Inst Infect Dis, Ft Detrick, MD USA

[3] Okairos, Rome, Italy

[4] Ctr Ingn Genet CEINGE, Naples, Italy

[5] Univ Naples Federico II, Dept Mol Med & Med Biotechnol, Naples, Italy

[6] Keires AG, Basel, Switzerland

来源：

NATURE MEDICINE | 2014年 / 20卷 / 10期

关键词：

NONHUMAN-PRIMATES; VIRUS INFECTION; VECTOR; IMMUNOGENICITY; QUALITY;

D O I：

10.1038/nm.3702

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ebolavirus disease causes high mortality, and the current outbreak has spread unabated through West Africa. Human adenovirus type 5 vectors (rAd5) encoding ebolavirus glycoprotein (GP) generate protective immunity against acute lethal Zaire ebolavirus (EBOV) challenge in macaques, but fail to protect animals immune to Ad5, suggesting natural Ad5 exposure may limit vaccine efficacy in humans. Here we show that a chimpanzee-derived replication-defective adenovirus (ChAd) vaccine also rapidly induced uniform protection against acute lethal EBOV challenge in macaques. Because protection waned over several months, we boosted ChAd3 With modified vaccinia Ankara (MVA) and generated, for the first time, durable protection against lethal EBOV Challenge.

引用

页码：1126 / 1129

页数：4

共 22 条

[1] Novel Adenovirus-Based Vaccines Induce Broad and Sustained T Cell Responses to HCV in Man [J].

Barnes, Eleanor ;

Folgori, Antonella ;

Capone, Stefania ;

Swadling, Leo ;

Aston, Stephen ;

Kurioka, Ayako ;

Meyer, Joel ;

Huddart, Rachel ;

Smith, Kira ;

Townsend, Rachel ;

Brown, Anthony ;

Antrobus, Richard ;

Ammendola, Virginia ;

Naddeo, Mariarosaria ;

O'Hara, Geraldine ;

Willberg, Chris ;

Harrison, Abby ;

Grazioli, Fabiana ;

Esposito, Maria Luisa ;

Siani, Loredana ;

Traboni, Cinzia ;

Oo, Ye ;

Adams, David ;

Hill, Adrian ;

Colloca, Stefano ;

Nicosia, Alfredo ;

Cortese, Riccardo ;

Klenerman, Paul .

SCIENCE TRANSLATIONAL MEDICINE, 2012, 4 (115)

[2] Immunogenicity of recombinant adenovirus serotype 35 vaccine in the presence of pre-existing anti-Ad5 immunity [J].

Barouch, DH ;

Pau, MG ;

Custers, JHHV ;

Koudstaal, W ;

Kostense, S ;

Havenga, MJE ;

Truitt, DM ;

Sumida, SM ;

Kishko, MG ;

Arthur, JC ;

Korioth-Schmitz, B ;

Newberg, MH ;

Gorgone, DA ;

Lifton, MA ;

Panicali, DL ;

Nabel, GJ ;

Letvin, NL ;

Goudsmit, J .

JOURNAL OF IMMUNOLOGY, 2004, 172 (10) :6290-6297

[3] Heterologous Prime-Boost HIV-1 Vaccination Regimens in Pre-Clinical and Clinical Trials [J].

Brown, Scott A. ;

Surman, Sherri L. ;

Sealy, Robert ;

Jones, Bart G. ;

Slobod, Karen S. ;

Branum, Kristen ;

Lockey, Timothy D. ;

Howlett, Nanna ;

Freiden, Pamela ;

Flynn, Patricia ;

Hurwitz, Julia L. .

VIRUSES-BASEL, 2010, 2 (02) :435-467

[4] Vaccine Vectors Derived from a Large Collection of Simian Adenoviruses Induce Potent Cellular Immunity Across Multiple Species [J].

Colloca, Stefano ;

Barnes, Eleanor ;

Folgori, Antonella ;

Ammendola, Virginia ;

Capone, Stefania ;

Cirillo, Agostino ;

Siani, Loredana ;

Naddeo, Mariarosaria ;

Grazioli, Fabiana ;

Esposito, Maria Luisa ;

Ambrosio, Maria ;

Sparacino, Angela ;

Bartiromo, Marta ;

Meola, Annalisa ;

Smith, Kira ;

Kurioka, Ayako ;

O'Hara, Geraldine A. ;

Ewer, Katie J. ;

Anagnostou, Nicholas ;

Bliss, Carly ;

Hill, Adrian V. S. ;

Traboni, Cinzia ;

Klenerman, Paul ;

Cortese, Riccardo ;

Nicosia, Alfredo .

SCIENCE TRANSLATIONAL MEDICINE, 2012, 4 (115)

[5] Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major [J].

Darrah, Patricia A. ;

Patel, Dipti T. ;

De Luca, Paula M. ;

Lindsay, Ross W. B. ;

Davey, Dylan F. ;

Flynn, Barbara J. ;

Hoff, Soren T. ;

Andersen, Peter ;

Reed, Steven G. ;

Morris, Sheldon L. ;

Roederer, Mario ;

Seder, Robert A. .

NATURE MEDICINE, 2007, 13 (07) :843-850

[6] Recombinant Adenovirus Serotype 26 (Ad26) and Ad35 Vaccine Vectors Bypass Immunity to Ad5 and Protect Nonhuman Primates against Ebolavirus Challenge [J].

Geisbert, Thomas W. ;

Bailey, Michael ;

Hensley, Lisa ;

Asiedu, Clement ;

Geisbert, Joan ;

Stanley, Daphne ;

Honko, Anna ;

Johnson, Joshua ;

Mulangu, Sabue ;

Pau, Maria Grazia ;

Custers, Jerome ;

Vellinga, Jort ;

Hendriks, Jenny ;

Jahrling, Peter ;

Roederer, Mario ;

Goudsmit, Jaap ;

Koup, Richard ;

Sullivan, Nancy J. .

JOURNAL OF VIROLOGY, 2011, 85 (09) :4222-4233

[7] Vector Choice Determines Immunogenicity and Potency of Genetic Vaccines against Angola Marburg Virus in Nonhuman Primates [J].

Geisbert, Thomas W. ;

Bailey, Michael ;

Geisbert, Joan B. ;

Asiedu, Clement ;

Roederer, Mario ;

Grazia-Pau, Maria ;

Custers, Jerome ;

Jahrling, Peter ;

Goudsmit, Jaap ;

Koup, Richard ;

Sullivan, Nancy J. .

JOURNAL OF VIROLOGY, 2010, 84 (19) :10386-10394

[8] Demonstration of Cross-Protective Vaccine Immunity against an Emerging Pathogenic Ebolavirus Species [J].

Hensley, Lisa E. ;

Mulangu, Sabue ;

Asiedu, Clement ;

Johnson, Joshua ;

Honko, Anna N. ;

Stanley, Daphne ;

Fabozzi, Giulia ;

Nichol, Stuart T. ;

Ksiazek, Thomas G. ;

Rollin, Pierre E. ;

Wahl-Jensen, Victoria ;

Bailey, Michael ;

Jahrling, Peter B. ;

Roederer, Mario ;

Koup, Richard A. ;

Sullivan, Nancy J. .

PLOS PATHOGENS, 2010, 6 (05) :1-9

[9] Chimpanzee adenovirus vaccine protects against Zaire Ebola virus [J].

Kobinger, GP ;

Feldmann, H ;

Zhi, Y ;

Schumer, G ;

Gao, GP ;

Feldmann, F ;

Jones, S ;

Wilson, JM .

VIROLOGY, 2006, 346 (02) :394-401

[10] A replication defective recombinant Ad5 vaccine expressing Ebola virus GP is safe and immunogenic in healthy adults [J].

Ledgerwood, J. E. ;

Costner, P. ;

Desai, N. ;

Holman, L. ;

Enama, M. E. ;

Yamshchikov, G. ;

Mulangu, S. ;

Hu, Z. ;

Andrews, C. A. ;

Sheets, R. A. ;

Koup, R. A. ;

Roederer, M. ;

Bailer, R. ;

Mascola, J. R. ;

Pau, M. G. ;

Sullivan, N. J. ;

Goudsmit, J. ;

Nabel, G. J. ;

Graham, B. S. .

VACCINE, 2010, 29 (02) :304-313

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