Cooperative catalysis of a cationic ruthenium complex, amine base, and Na salt: Catalytic activation of acetonitrile as a nucleophile

被引：149

作者：

Kumagai, N ^{[1
]}

Matsunaga, S ^{[1
]}

Shibasaki, M ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 42期

关键词：

D O I：

10.1021/ja0450509

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cooperative catalysis of a cationic Ru complex, DBU, and NaPF6 is described. An exquisite combination of the catalytic triad enabled catalytic activation of acetonitrile as a nucleophile under mild amine-basic conditions. Addition of in situ-generated, Ru-bound, metalated nitrile to aldehydes and imines proceeded smoothly with 2.5-5 mol % Ru complex and 2.5-10 mol % DBU in the presence of 10 mol % NaPF6. Preliminary mechanistic studies suggested a role for each of the three catalytic components. Copyright © 2004 American Chemical Society.

引用

页码：13632 / 13633

页数：2

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