Intramolecular nonbonded S•••O interaction recognized in (acylimino)thiadiazoline derivatives as angiotensin II receptor antagonists and related compounds

被引：254

作者：

Nagao, Y ^{[1
]}

Hirata, T

Goto, S

Sano, S

Kakehi, A

Iizuka, K

Shiro, M

机构：

[1] Univ Tokushima, Fac Pharmaceut Sci, Sho, Tokushima 770, Japan

[2] Wakunaga Pharmaceut Co Ltd, Inst Med Res, Koda, Hiroshima 73911, Japan

[3] Shinshu Univ, Fac Engn, Nagano 380, Japan

[4] Kissei Pharmaceut Co Ltd, Hotaka, Nagano 39983, Japan

[5] Rigaku Corp, Tokyo 196, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1998年 / 120卷 / 13期

关键词：

D O I：

10.1021/ja973109o

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The intramolecular nonbonded 1,5-type S ... O interactions are recognized in the crystalline structures of the (acylimino)thiadiazoline derivatives (1-3) as angiotensin II receptor antagonists. The relative stability of the nonbonded 1,5-type S ... O interaction was investigated using the X-ray crystallographic analyses and the ab initio MO calculations (HF/3-21G*, 6-31G*, and 6-311+G**) of the simplified model compounds (6, 7, and 9). The concept of mimic-fused bicyclic heterocycles consisting of fairly stable nonbonded S ... O interaction seems to be an efficient approach toward the design and development of various drugs.

引用

页码：3104 / 3110

页数：7

共 31 条

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