Comparative in vitro bactericidal activity between cefepime and ceftazidime, alone and associated with amikacin, against carbapenem-resistant Pseudomonas aeruginosa strains

被引：11

作者：

Bantar, C ^{[1
]}

Di Chiara, M ^{[1
]}

Nicola, F ^{[1
]}

Relloso, S ^{[1
]}

Smayevsky, J ^{[1
]}

机构：

[1] Ctr Educ Med & Invest Clin Dr Norberto Quirno, Dept Microbiol, RA-1425 Buenos Aires, DF, Argentina

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2000年 / 37卷 / 01期

关键词：

D O I：

10.1016/S0732-8893(99)00156-X

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Fifteen unique isolates of carbapenem-resistant Pseudomonas aeruginosa were selected for time-kill studies to assess the bactericidal activity of cefepime (CFP) and ceftazidime (CZD) (at 4 and 16 mu g/mL), alone and associated with amikacin (AMK) (4 mu g/mL). CFP proved more active than CZD (p < 0.05, Student's t test). Bactericidal activity after 24-h incubation was only achieved by the combination of CFP (16 mu g/mL) plus AMK. The higher in vitro activity of cefepime over that of ceftazidime against imipenem-resistant P. aeruginosa strains highlights the differences of these drugs beyond Enterobacter spp. and Staphylococcus aureus. (C) 2000 Elsevier Science Inc. All rights reserved.

引用

页码：41 / 44

页数：4

共 13 条

[11] Resistance to β-lactam antibiotics in Pseudomonas aeruginosa due to interplay between the MexAB-OprM efflux pump and β-lactamase [J].

Nakae, T ;

Nakajima, A ;

Ono, T ;

Saito, K ;

Yoneyama, H .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (05) :1301-1303

[12]

*NAT COMM CLIN LAB, 1997, M7A4

[13] Imipenem-resistant Pseudomonas aeruginosa: Risk factors and antibiotic susceptibility patterns [J].

Troillet, N ;

Samore, MH ;

Carmeli, Y .

CLINICAL INFECTIOUS DISEASES, 1997, 25 (05) :1094-1098

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