Wnt signaling enhances the activation and survival of human hepatic stellate cells

被引：104

作者：

Myung, Sun Jung

Yoon, Jung-Hwan ^{[1
]}

Gwak, Geum-Youn

Kim, Won

Lee, Jeong-Hoon

Kim, Kang Mo

Shin, Chan Soo

Jang, Ja June

Lee, Sung-Hee

Lee, Soo-Mi

Lee, Hyo-Suk

机构：

[1] Seoul Natl Univ, Coll Med, Liver Res Inst, Dept Internal Med, Seoul, South Korea

[2] Seoul Natl Univ, Coll Med, Dept Pathol, Seoul 151, South Korea

来源：

FEBS LETTERS | 2007年 / 581卷 / 16期

关键词：

hepatic stellate cell; fibrosis; Wnt; secreted frizzled-related protein 1; apoptosis;

D O I：

10.1016/j.febslet.2007.05.050

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Wnt signaling was implicated in pulmonary and renal fibrosis. Since Wnt activity is enhanced in liver cirrhosis, Wnt signaling may also participate in hepatic fibrogenesis. Thus, we determined if Writ signaling modulates hepatic stellate cell (HSC) activation and survival. Wnt3A treatment significantly activated human HSCs, while this was inhibited in secreted frizzled-related protein 1 (sFRP1) overexpressing cells. Wnt3A treatment significantly suppressed TRAIL-induced apoptosis in control HSCs versus sFRP1 over-expressing cells. Particularly, caspase 3 was more activated in sFRP1 over-expressing cells following TRAIL and Wnt3A treatment. These observations imply that Wnt signaling promotes hepatic fibrosis by enhancing HSC activation and survival. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：2954 / 2958

页数：5

共 15 条

[1] Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury [J].