Peptide-cleaving catalyst selective for peptide deformylase

被引：60

作者：

Chae, PS ^{[1
]}

Kim, MS ^{[1
]}

Jeung, CS ^{[1
]}

Du Lee, S ^{[1
]}

Park, H ^{[1
]}

Lee, S ^{[1
]}

Suh, J ^{[1
]}

机构：

[1] Seoul Natl Univ, Dept Chem, Seoul 151747, South Korea

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 08期

关键词：

D O I：

10.1021/ja044043h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A peptide-cleaving catalyst selective for peptide deformylase (PDF) was obtained from a library containing about 15000 catalyst candidates. The catalyst cleaved the polypeptide backbone of PDF at Gln(152)-Arg(153). Docking simulations suggested multiple modes of interactions in the complex formed between the catalyst and PDF. Copyright © 2005 American Chemical Society.

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页码：2396 / 2397

页数：2

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