Appendectomy, smoking habits and the risk of developing ulcerative colitis: a case control study in private practice setting

被引:21
作者
de Saussure, Philippe
Clerson, Pierre
Prost, Pierre-Louis
Tan, Nghiep Truong
Bouhnik, Yoram
机构
[1] Hop Beaujon, Serv Gastroenterol & Assistance Nutrit, F-92110 Clichy, France
[2] Grp Gastroenterol Invest Liberaux Sur RCH, Paris, France
[3] Hop Cantonal Univ Geneva, Div Gastroenterol & Hepatol, Geneva, Switzerland
[4] Cascade Pharma, Paris, France
[5] Cell Tech Pharma, Paris, France
来源
GASTROENTEROLOGIE CLINIQUE ET BIOLOGIQUE | 2007年 / 31卷 / 05期
关键词
D O I
10.1016/S0399-8320(07)89417-6
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Objectives - The strongest environmental factors identified for ulcerative colitis (UC) are cigarette smoking and appendectomy. However, most studies have been performed using case-controls from hospital-based populations. The purpose of this study was to compare the history of previous appendectomy and smoking habits in a group of patients with UC and a control group, followed by gastroenterologists in private practice. Methods - We performed a case control study in which 100 physicians recruited UC-patients and age and sex matched controls. Data were collected during a single visit. Based on a standardized questionnaire, UC patients and controls were divided into never, former or current smokers, and into subjects with or without a previous history of appendectomy. Results - One hundred and ninety eight age- and sex-matched pairs of UC patients and controls were included. The prevalence of appendectomy in the UC-patients and control group was 12% and 46%, respectively. The pairwise-matched OR of ulcerative colitis for previous appendectomy was 0.10 (95% Cl, 0.05-0.21) (P < 0.0001). The OR for former and never smokers versus current smokers was 2.40 (95% Cl 1.31-4.38) (P=0.004). In UC-patients, the OR of family history of UC compared with controls was 2.80 (95% CI, 1.01-7.77) (P=0.048). Conclusions - This case-control study confirmed a strong negative correlation between both appendectomy and tobacco smoking, and ulcerative colitis in patients followed-up by gastroenterological practitioners.
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收藏
页码:493 / 497
页数:5
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