Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats

被引：24

作者：

Dong, Deshi ^{[1
,2
,3
]}

Qi, Yan ^{[1
]}

Xu, Lina ^{[1
]}

Yin, Lianhong ^{[1
]}

Xu, Youwei ^{[1
]}

Han, Xu ^{[1
]}

Zhao, Yanyan ^{[1
]}

Peng, Jinyong ^{[1
,2
]}

机构：

[1] Dalian Med Univ, Coll Pharm, Dalian 116044, Peoples R China

[2] Dalian Med Univ, Res Inst Integrated Tradit & Western Med, Dalian 116011, Peoples R China

[3] Dalian Med Univ, Affiliated Hosp 1, Dalian 116011, Peoples R China

来源：

FOOD & FUNCTION | 2014年 / 5卷 / 12期

关键词：

LIVER-DISEASE; OXIDATIVE STRESS; HEME OXYGENASE-1; ACID; METABOLISM; STEATOHEPATITIS; TRIGLYCERIDE; ACTIVATION; FLAVONOIDS; GLUTAMATE;

D O I：

10.1039/c4fo00491d

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The protective effects of total saponins from Rosa laevigata Michx fruit (RLTS) in high-fat diet (HFD)-induced rats were investigated. The results showed that oral administration of RLTS attenuated hepatic steatosis, significantly reduced the levels of body weight, alanine transaminase, aspartate transaminase, total cholesterol, total triglyceride, free fatty acids, low density lipoprotein, blood glucose, insulin and malondialdehyde, and increased high density lipoprotein and glutathione levels compared with the model group. Further investigations showed that RLTS affected fatty acid synthesis, fatty acid beta-oxidation, fatty acid omega-oxidation, total cholesterol and triglyceride metabolism and synthesis. Moreover, the extract obviously suppressed HFD-induced oxidative stress and inflammation. These results suggest that RLTS should be developed to be one functional food or health product against non-alcoholic fatty liver disease (NAFLD) in the future.

引用

页码：3065 / 3075

页数：11

共 67 条

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Lipid-lowering effects of methanolic extract of Vernonia amygdalina leaves in rats fed on high cholesterol diet [J].