Does Chronic Microaspiration Cause Idiopathic Pulmonary Fibrosis?

被引：152

作者：

Lee, Joyce S. ^{[1
]}

Collard, Harold R. ^{[1
]}

Raghu, Ganesh ^{[3
]}

Sweet, Matthew P. ^{[2
]}

Hays, Steven R. ^{[1
]}

Campos, Guilherme M. ^{[2
]}

Golden, Jeffrey A. ^{[1
]}

King, Talmadge E., Jr. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Surg, San Francisco, CA 94143 USA

[3] Univ Washington, Dept Med, Seattle, WA USA

来源：

AMERICAN JOURNAL OF MEDICINE | 2010年 / 123卷 / 04期

关键词：

Diagnostic techniques and procedures; Etiology; Gastroesophageal reflux; Pulmonary fibrosis; Respiratory aspiration; ACID GASTROESOPHAGEAL-REFLUX; EXHALED BREATH CONDENSATE; ASPIRATION PNEUMONITIS; HIGH PREVALENCE; PEPSIN ASSAY; BILE-ACIDS; DISEASE; FUNDOPLICATION; ESOPHAGUS; MUTATIONS;

D O I：

10.1016/j.amjmed.2009.07.033

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Idiopathic pulmonary fibrosis is a diffuse fibrotic lung disease of unknown etiology with no effective treatment. Emerging data support a role for chronic microaspiration (ie, subclinical aspiration of small droplets) in the pathogenesis and natural history of idiopathic pulmonary fibrosis. However, the precise relationship between chronic microaspiration and idiopathic pulmonary fibrosis remains unknown. Gastroesophageal reflux, a presumed risk factor for microaspiration, has been strongly associated with idiopathic pulmonary fibrosis with an estimated prevalence of up to 90%. This review aims to describe the relationship between chronic microaspiration and idiopathic pulmonary fibrosis by laying out the clinical and biologic rationale for this relationship and exploring the scientific evidence available. The gaps in our current understanding of the diagnosis of chronic microaspiration and idiopathic pulmonary fibrosis and the ongoing uncertainties in management and treatment will be highlighted. Defining the role of chronic microaspiration in idiopathic pulmonary fibrosis is essential as it has potential clinical, pathobiological, and treatment implications for this deadly disease. (C) 2010 Elsevier Inc. All rights reserved. The American Journal of Medicine (2010) 123, 304-311

引用

页码：304 / 311

页数：8

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