Th2 and eosinophil responses suppress inflammatory arthritis

被引：135

作者：

Chen, Zhu ^{[1
,2
,3
]}

Andreev, Darja ^{[1
,2
]}

Oeser, Katharina ^{[4
,5
]}

Krljanac, Branislav ^{[4
,5
]}

Hueber, Axel ^{[1
,2
]}

Kleyer, Arnd ^{[1
,2
]}

Voehringer, David ^{[4
,5
]}

Schett, Georg ^{[1
,2
]}

Bozec, Aline ^{[1
,2
]}

机构：

[1] Univ Hosp Erlangen, Dept Internal Med 3, Gluckstr 6, D-91054 Erlangen, Germany

[2] Univ Erlangen Nurnberg, Gluckstr 6, D-91054 Erlangen, Germany

[3] Anhui Med Univ, Affiliated Prov Hosp, Dept Rheumatol & Immunol, Hefei 230001, Peoples R China

[4] Univ Hosp Erlangen, Dept Infect Biol, D-91054 Erlangen, Germany

[5] Friedrich Alexander Univ Erlangen Nuremberg FAU, D-91054 Erlangen, Germany

来源：

NATURE COMMUNICATIONS | 2016年 / 7卷

基金：

中国国家自然科学基金;

关键词：

COLLAGEN-INDUCED ARTHRITIS; TUMOR-NECROSIS-FACTOR; RHEUMATOID-ARTHRITIS; HELMINTH INFECTION; TISSUE-DAMAGE; T-CELL; NIPPOSTRONGYLUS-BRASILIENSIS; AIRWAY INFLAMMATION; BONE DESTRUCTION; TYPE-2; IMMUNITY;

D O I：

10.1038/ncomms11596

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Th2-eosinophil immune responses are well known for mediating host defence against helminths. Herein we describe a function of Th2-eosinophil responses in counteracting the development of arthritis. In two independent models of arthritis, Nippostrongylus brasiliensis infection leads to Th2 and eosinophil accumulation in the joints associated with robust inhibition of arthritis and protection from bone loss. Mechanistically, this protective effect is dependent on IL-4/IL-13-induced STAT6 pathway. Furthermore, we show that eosinophils play a central role in the modulation of arthritis probably through the increase of anti-inflammatory macrophages into arthritic joints. The presence of these pathways in human disease is confirmed by detection of GATA3-positive cells and eosinophils in the joints of rheumatoid arthritis patients. Taken together, these results demonstrate that eosinophils and helminth-induced activation of the Th2 pathway axis effectively mitigate the course of inflammatory arthritis.

引用

页数：12

共 49 条

[1]

Protective immune mechanisms in helminth infection [J].