Imaging single mammalian cells with a 1.5 T clinical MRI scanner

被引：179

作者：

Foster-Gareau, P ^{[1
]}

Heyn, C ^{[1
]}

Alejski, A ^{[1
]}

Rutt, BK ^{[1
]}

机构：

[1] John P Robarts Res Inst, Imaging Res Labs, London, ON N6A 5K8, Canada

来源：

MAGNETIC RESONANCE IN MEDICINE | 2003年 / 49卷 / 05期

关键词：

magnetic resonance imaging; cells; iron oxide; microimaging; cell labeling;

D O I：

10.1002/mrm.10417

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

In the present work, we demonstrate that the steady-state free precession (SSFP) imaging pulse sequence FIESTA (fast imaging employing steady state acquisition) used in conjunction with a custom-built insertable gradient coil and customized RF coils can be used to detect individual SPIO-labeled cells using a commonly available 1.5 T clinical MRI scanner. This work provides the first evidence that single-cell tracking will be possible using clinical MRI scanners, opening up new possibilities for cell tracking and monitoring of cellular therapeutics in vivo in humans. (C) 2003 Wiley-Liss, Inc.

引用

页码：968 / 971

页数：4

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