Role of branched-chain amino acids in liver disease: the evidence for and against

被引:39
作者
Khanna, Sudeep
Gopalan, Sarath
机构
[1] Pushpawati Singhania Res Inst Liver Renal & Diges, New Delhi 110017, India
[2] CRNSS, New Delhi, India
关键词
branched-chain amino acids; hepatic encephalopathy; liver disease;
D O I
10.1097/MCO.0b013e3280d646b8
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Purpose of review There is ample evidence that patients with liver disease have an ongoing energy and protein catabolism. Nutritional management in these patients must receive high priority. The administration of branched-chain amino acids to patients with liver disease has been a controversial subject. This review is an update on the data available from various studies involving branched-chain amino acids supplementation in patients with chronic liver disease and associated complications. Recent findings This review summarizes the results of nutritional interventions involving branched-chain amino acids supplementation carried out in different centres around the world. It is interesting to note that no toxic effects of branched-chain amino acids supplementation have been reported in any of these trials. Summary Administration of branched-chain amino acids stimulates hepatic protein synthesis in patients with chronic liver disease and this could contribute significantly to improving their nutritional status, and result in a better quality of life. The beneficial role of branched-chain amino acids supplementation in patients with chronic hepatic encephalopathy has been clearly documented in some studies but the exact mechanism of action is still not clear.
引用
收藏
页码:297 / 303
页数:7
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