Dynamics of the human EEG during prolonged wakefulness: evidence for frequency-specific circadian and homeostatic influences

被引：152

作者：

Aeschbach, D ^{[1
]}

Matthews, JR ^{[1
]}

Postolache, TT ^{[1
]}

Jackson, MA ^{[1
]}

Giesen, HA ^{[1
]}

Wehr, TA ^{[1
]}

机构：

[1] NIMH, Clin Psychobiol Branch, Bethesda, MD 20892 USA

来源：

NEUROSCIENCE LETTERS | 1997年 / 239卷 / 2-3期

关键词：

electroencephalogram; spectral analysis; circadian rhythm; homeostatic process; constant routine protocol; evening wake-maintenance; sleepiness; body temperature;

D O I：

10.1016/S0304-3940(97)00904-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The electroencephalogram (EEG) of nine healthy individuals was recorded at half-hourly intervals during similar to 40 h of sustained wakefulness in a constant routine protocol. EEG power density in the 0.75-9.0 Hz range exhibited a global increasing trend, and a local trough in the evening, centered similar to 6 h prior to the temperature minimum. The former could be attributed to a wake-dependent influence, and the latter to a circadian influence. Power density in the 9.25-12.0 Hz band showed a circadian modulation, the trough coinciding with the minimum of the endogenous rhythm of body temperature, whereas a wake-dependent influence was not evident. Power density in the 12.25-25.0 Hz range exhibited a wake-dependent increase, whereas a circadian modulation was absent. It is concluded that the circadian pacemaker and the wake-dependent (i.e. homeostatic) process affect the waking EEG in a frequency-specific manner. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：121 / 124

页数：4

共 20 条

[1] Dynamics of EEG spindle frequency activity during extended sleep in humans: Relationship to slow-wave activity and time of day [J].