Correlation between MMP-13 and HDAC7 expression in human knee osteoarthritis

被引：111

作者：

Higashiyama, Reiji ^{[1
,2
,3
]}

Miyaki, Shigeru ^{[2
]}

Yamashita, Satoshi ^{[1
]}

Yoshitaka, Teruhito ^{[1
]}

Lindman, Goerel ^{[1
]}

Ito, Yoshiaki ^{[1
]}

Sasho, Takahisa ^{[3
]}

Takahashi, Kazuhisa ^{[3
]}

Lotz, Martin ^{[2
]}

Asahara, Hiroshi ^{[1
,2
]}

机构：

[1] Natl Res Inst Child Hlth & Dev, Dept Syst BioMed, Setagaya Ku, Tokyo 1578535, Japan

[2] Scripps Res Inst, Div Arthrit Res, La Jolla, CA 92037 USA

[3] Chiba Univ, Dept Orthopaed Surg, Grad Sch Med, Chiba, Japan

来源：

MODERN RHEUMATOLOGY | 2010年 / 20卷 / 01期

关键词：

Osteoarthritis; HDAC7 and MMP-13; HISTONE-DEACETYLASE INHIBITORS; GENE-EXPRESSION; TRICHOSTATIN-A; INDUCED ARTHRITIS; MESSENGER-RNA; IN-VIVO; CARTILAGE; MATRIX; CHONDROCYTES; COLLAGENASE;

D O I：

10.1007/s10165-009-0224-7

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Recent studies suggest that histone deacetylase (HDAC) inhibitors may therapeutically prevent cartilage degradation in osteoarthritis (OA). Matrix metalloproteinase-13 (MMP-13) plays an important role in the pathogenesis of this disease and in the present study we investigated the correlation between HDACs and MMP-13. Comparing the expression of different HDACs in cartilage from OA patients and healthy donors, HDAC7 showed a significant elevation in cartilage from OA patients. High level of HDAC7 expression in OA cartilage was also confirmed by immunohistochemistry. Knockdown of HDAC7 by small interference RNA (siRNA) in SW1353 human chondrosarcoma cells strongly suppressed interleukin (IL)-1-dependent and independent induction of MMP-13 gene expression. In conclusion, elevated HDAC7 expression in human OA may contribute to cartilage degradation via promoting MMP-13 gene expression, suggesting the critical role of MMP-13 in OA pathogenesis.

引用

页码：11 / 17

页数：7

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