Epigenetic reprogramming in early mammalian development and following somatic nuclear transfer

被引：199

作者：

Dean, W ^{[1
]}

Santos, F ^{[1
]}

Reik, W ^{[1
]}

机构：

[1] Babraham Inst, Lab Dev Genet & Imprinting, Dev Genet Programme, Cambridge CB2 4AT, England

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2003年 / 14卷 / 01期

基金：

英国生物技术与生命科学研究理事会;

关键词：

DNA methylation; epigenetic reprogramming; totipotency;

D O I：

10.1016/S1084-9521(02)00141-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Epigenetic modifications of the genome play a significant role in the elaboration of the genetic code as established at fertilisation. These modifications affect early growth and development through their influence on gene expression especially on imprinted genes. Genome-wide epigenetic reprogramming in germ cells is essential in order to reset the parent-of-origin specific marking of imprinted genes, but may have a more general role in the restoration of totipotency in the early embryo. In a similar way, on somatic nuclear cloning, a differentiated cell must become 'reprogrammed' restoring totipotency in order to undergo development. Here we discuss the dynamic epigenetic reprogramming that takes place during normal development and highlight those areas with relevance to somatic nuclear cloning and the possibility of improving the efficiency of this process. We propose the concept of 'epigenetic checkpoints' for normal progression of development and the loss of totipotency. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：93 / 100

页数：8

共 40 条

[1]

Arney KL, 2002, INT J DEV BIOL, V46, P317

[2] The DNA methyltransferases of mammals [J].

Bestor, TH .

HUMAN MOLECULAR GENETICS, 2000, 9 (16) :2395-2402

[3] DNA methylation patterns and epigenetic memory [J].

Bird, A .

GENES & DEVELOPMENT, 2002, 16 (01) :6-21

[4] Oct4 distribution and level in mouse clones:: consequences for pluripotency [J].

Boiani, M ;

Eckardt, S ;

Schöler, HR ;

McLaughlin, KJ .

GENES & DEVELOPMENT, 2002, 16 (10) :1209-1219

[5] Delayed and incomplete reprogramming of chromosome methylation patterns in bovine cloned embryos [J].

Bourc'his, D ;

Le Bourhis, D ;

Patin, D ;

Niveleau, A ;

Comizzoli, P ;

Renard, JP ;

Viegas-Péquignot, E .

CURRENT BIOLOGY, 2001, 11 (19) :1542-1546

[6] From intestine to muscle: Nuclear reprogramming through defective cloned embryos [J].

Byrne, JA ;

Simonsson, S ;

Gurdon, JB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (09) :6059-6063

[7] PROPERTIES AND LOCALIZATION OF DNA METHYLTRANSFERASE IN PREIMPLANTATION MOUSE EMBRYOS - IMPLICATIONS FOR GENOMIC IMPRINTING [J].

CARLSON, LL ;

PAGE, AW ;

BESTOR, TH .

GENES & DEVELOPMENT, 1992, 6 (12B) :2536-2541

[8] Heterochromatin, HP1 and methylation at lysine 9 of histone H3 in animals [J].

Cowell, IG ;

Aucott, R ;

Mahadevaiah, SK ;

Burgoyne, PS ;

Huskisson, N ;

Bongiorni, S ;

Prantera, G ;

Fanti, L ;

Pimpinelli, S ;

Wu, R ;

Gilbert, DM ;

Shi, W ;

Fundele, R ;

Morrison, H ;

Jeppesen, P ;

Singh, PB .

CHROMOSOMA, 2002, 111 (01) :22-36

[9] Conservation of methylation reprogramming in mammalian development: Aberrant reprogramming in cloned embryos [J].

Dean, W ;

Santos, F ;

Stojkovic, M ;

Zakhartchenko, V ;

Walter, J ;

Wolf, E ;

Reik, W .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (24) :13734-13738

[10] Epigenetic reprogramming in mouse primordial germ cells [J].

Hajkova, P ;

Erhardt, S ;

Lane, N ;

Haaf, T ;

El-Maarri, O ;

Reik, W ;

Walter, J ;

Surani, MA .

MECHANISMS OF DEVELOPMENT, 2002, 117 (1-2) :15-23

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