The immune response to chronic Pseudomonas aeruginosa lung infection in cystic fibrosis patients is predominantly of the Th2 type

被引:133
作者
Moser, C
Kjaergaard, S
Pressler, T
Kharazmi, A
Koch, C
Hoiby, N
机构
[1] Univ Copenhagen Hosp, Rigshosp, Dept Clin Microbiol 9301, Ctr Lab Med & Pathol, DK-2100 Copenhagen O, Denmark
[2] Univ Copenhagen Hosp, Rigshosp, Dept Pediat, Danish Cyst Fibrosis Ctr, DK-2100 Copenhagen, Denmark
关键词
Pseudomonas aeruginosa; cystic fibrosis; Th1/Th2; response;
D O I
10.1034/j.1600-0463.2000.d01-64.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Most cystic fibrosis (CF) patients with chronic Pseudomonas aeruginosa lung infection have a persistent acute type lung inflammation dominated by polymorphonuclear neutrophils (PMN) and a pronounced antibody response against P. aeruginosa. We speculated whether this immune response in CF is of the Th2 type and whether a change to a Th1 type immune response could improve the prognosis. Therefore, we studied 14 CF patients with (CF +P) and 14 CF patients without (CF -P) chronic P. aeruginosa lung infection. The specific production of interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) by peripheral blood mononuclear cells was determined. Cells from CF +P patients had lower IFN-gamma (p<0.05) and higher IL-4 (p<0.005) production as compared to cells from CF -P patients. Furthermore, a positive correlation between IFN-gamma production and lung function was found (FVC: Rho=0.637; p<0.03; FEV1: Rho=0.524; p<0.07). We conclude that a Th2 type immune response is most frequent in CF patients with chronic P. aeruginosa lung infection, and the patients with a Th1-dominated immune response had the best lung function. The clinical implication is that a change to a Th1 type immune response might improve the prognosis in these patients.
引用
收藏
页码:329 / 335
页数:7
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