Anti-endotoxin antibodies in human milk: correlation with infection of the newborn

被引:7
作者
Feist, N
Berger, D
Speer, CP
机构
[1] Univ Tubingen, Dept Anaesthesiol, D-72076 Tubingen, Germany
[2] Dept Gen Surg, Baden Baden, Germany
[3] Univ Wurzburg, Childrens Hosp, Wurzburg, Germany
关键词
endotoxin antibodies; human milk; neonatal infection; prematurity;
D O I
10.1080/713794575
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
A longitudinal study was performed to investigate the content of human colostrum and milk of antibodies against endotoxins of Escherichia coli, Pseudomonas aeruginosa and Salmonella minnesota during the first 6 mo of lactation. The influence of the gestational age of the newborn and the prevalence of a systemic infection in the child on maternal antibody production were observed. Colostrum of mothers of term infants who had shown signs of systemic infection contained higher antibody concentrations compared to colostrum of mothers of healthy newborns. After the first week post partum, no difference in the milk's antibody content could be observed between these two groups. Antibody titres rose from 2 wk to 6 mo post partum (p < 0.001). Milk of mothers of preterm infants with signs of systemic infection contained higher antibody titres than milk of mothers of preterm infants without infection throughout the observation period. This difference reached statistical significance 3 wk after delivery (p < 0.05). The corrected endotoxin antibody levels against all tested antigens in milk of mothers of preterm infants with infection 6 mo post partum were 6 +/- 3.5 times as high as 2 wk post partum. Conclusions: Breast milk contains anti-endotoxin antibodies. The particularly high levels of anti-endotoxin antibodies in cases of neonatal infection may present a special maternal protection for premature infants.
引用
收藏
页码:1087 / 1092
页数:6
相关论文
共 31 条
[1]   ANTIBODY-PRODUCTION BY HUMAN COLOSTRAL CELLS .1. IMMUNOGLOBULIN CLASS, SPECIFICITY, AND QUANTITY [J].
AHLSTEDT, S ;
CARLSSON, B ;
HANSON, LA ;
GOLDBLUM, RM .
SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1975, 4 (5-6) :535-539
[2]  
ALBANESE CT, 1994, J AM COLL SURGEONS, V179, P679
[3]  
ASHKENAZI S, 1994, ISRAEL J MED SCI, V30, P335
[4]   Body temperatures and oxygen consumption during skin-to-skin (kangaroo) care in stable preterm infants weighing less than 1500 grams [J].
Bauer, K ;
Uhrig, C ;
Sperling, P ;
Pasel, K ;
Wieland, C ;
Versmold, HT .
JOURNAL OF PEDIATRICS, 1997, 130 (02) :240-244
[5]   DAILY INGESTION OF IMMUNOLOGICAL COMPONENTS IN HUMAN-MILK DURING THE 1ST 4 MONTHS OF LIFE [J].
BUTTE, NF ;
GOLDBLUM, RM ;
FEHL, LM ;
LOFTIN, K ;
SMITH, EO ;
GARZA, C ;
GOLDMAN, AS .
ACTA PAEDIATRICA SCANDINAVICA, 1984, 73 (03) :296-301
[6]   ESCHERICHIA-COLI O ANTIBODY CONTENT IN MILK FROM HEALTHY SWEDISH MOTHERS AND MOTHERS FROM A VERY LOW SOCIOECONOMIC GROUP OF A DEVELOPING-COUNTRY [J].
CARLSSON, B ;
AHLSTEDT, S ;
HANSON, LA ;
LIDINJANSON, G ;
LINDBLAD, BS ;
SULTANA, R .
ACTA PAEDIATRICA SCANDINAVICA, 1976, 65 (04) :417-423
[7]   PROSPECTIVE STUDIES OF THE EFFECT OF BREAST FEEDING ON INCIDENCE OF INFECTION AND ALLERGY [J].
CHANDRA, RK .
ACTA PAEDIATRICA SCANDINAVICA, 1979, 68 (05) :691-694
[8]   FLUCTUATION OF SPECIFIC IGA ANTIBODIES IN HUMAN-MILK [J].
CRUZ, JR ;
AREVALO, C .
ACTA PAEDIATRICA SCANDINAVICA, 1985, 74 (06) :897-903
[9]   STUDIES ON HUMAN-MILK .3. SECRETORY IGA QUANTITY AND ANTIBODY-LEVELS AGAINST ESCHERICHIA-COLI IN COLOSTRUM AND MILK FROM UNDERPRIVILEGED AND PRIVILEGED MOTHERS [J].
CRUZ, JR ;
CARLSSON, B ;
GARCIA, B ;
GEBREMEDHIN, M ;
HOFVANDER, Y ;
URRUTIA, JJ ;
HANSON, LA .
PEDIATRIC RESEARCH, 1982, 16 (04) :272-276
[10]   STUDIES OF HUMAN-MILK .2. CONCENTRATION OF ANTIBODIES AGAINST SALMONELLA AND SHIGELLA IN MILK OF WOMEN FROM DIFFERENT POPULATIONS AND THE DAILY INTAKE BY THEIR BREAST-FED INFANTS [J].
CRUZ, JR ;
CARLSSON, BVM ;
HOFVANDER, Y ;
HOLME, DT ;
HANSON, LA .
ACTA PAEDIATRICA SCANDINAVICA, 1985, 74 (03) :338-341