Mesenchymal stem cell therapy and acute graft-versus-host disease: a review

被引：115

作者：

Amorin, Bruna ^{[1
,2
]}

Alegretti, Ana Paula ^{[1
]}

Valim, Vanessa ^{[1
]}

Pezzi, Annelise ^{[1
,2
]}

Laureano, Alvaro Macedo ^{[1
,2
]}

Lima da Silva, Maria Aparecida ^{[1
]}

Wieck, Andrea ^{[1
]}

Silla, Lucia ^{[1
,2
,3
,4
]}

机构：

[1] Hosp Clin Porto Alegre, Expt Res Ctr, Cell Therapy Ctr, BR-90035903 Porto Alegre, RS, Brazil

[2] Univ Fed Rio Grande do Sul, Grad Program Med Med Sci, Porto Alegre, RS, Brazil

[3] Hosp Clin Porto Alegre, Dept Hematol, BR-90035903 Porto Alegre, RS, Brazil

[4] Hosp Clin Porto Alegre, BR-90035903 Porto Alegre, RS, Brazil

来源：

HUMAN CELL | 2014年 / 27卷 / 04期

关键词：

Mesenchymal stem cell; Graft-versus-host disease; Immunomodulation; Cell therapy; Inflammatory; MARROW STROMAL CELLS; TOLL-LIKE RECEPTORS; SUPPRESS T-LYMPHOCYTE; BONE-MARROW; PEDIATRIC-PATIENTS; INTERFERON-GAMMA; IN-VITRO; IMMUNOSUPPRESSIVE PROPERTIES; INDOLEAMINE 2,3-DIOXYGENASE; IMMUNOLOGICAL-PROPERTIES;

D O I：

10.1007/s13577-014-0095-x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Mesenchymal stem cells (MSCs) are being widely studied as potential cell therapy agents due to their immunomodulatory properties, which have been established by in vitro studies and in several clinical trials. Within this context, mesenchymal stem cell therapy appears to hold substantial promise, particularly in the treatment of conditions involving autoimmune and inflammatory components. Nevertheless, many research findings are still contradictory, mostly due to difficulties in characterization of the effects of MSCs in vivo. The purpose of this review is to report the mechanisms underlying mesenchymal stem cell therapy for acute graft-versus-host disease, particularly with respect to immunomodulation, migration, and homing, as well as report clinical applications described in the literature.

引用

页码：137 / 150

页数：14

共 144 条

[1]

Human mesenchymal stem cells modulate allogeneic immune cell responses [J].

Aggarwal, S ;

Pittenger, MF .

BLOOD, 2005, 105 (04) :1815-1822

[2]

Single intra-arterial injection of mesenchymal stromal cells for treatment of steroid-refractory acute graft-versus-host disease: a pilot study [J].

Arima, Nobuyoshi ;

Nakamura, Fumiaki ;

Fukunaga, Akiko ;

Hirata, Hirokazu ;

Machida, Hiroko ;

Kouno, Shigene ;

Ohgushi, Hajime .

CYTOTHERAPY, 2010, 12 (02) :265-268

[3]

Mesenchymal stem cells suppress B-cell terminal differentiation [J].

Asari, Sadaki ;

Itakura, Shin ;

Ferreri, Kevin ;

Liu, Chih-Pin ;

Kuroda, Yoshikazu ;

Kandeel, Fouad ;

Mullen, Yoko .

EXPERIMENTAL HEMATOLOGY, 2009, 37 (05) :604-615

[4]

Bone marrow mesenchymal progenitor cells inhibit lymphocyte proliferation by activation of the programmed death 1 pathway [J].

Augello, A ;

Tasso, R ;

Negrini, SM ;

Amateis, A ;

Indiveri, F ;

Cancedda, R ;

Pennesi, G .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2005, 35 (05) :1482-1490

[5]

Management of acute graft-versus-host disease [J].

Bacigalupo, Andrea .

BRITISH JOURNAL OF HAEMATOLOGY, 2007, 137 (02) :87-98

[6]

Cotransplantation of ex vivo-expanded mesenchymal stem cells accelerates lymphocyte recovery and may reduce the risk of graft failure in haploidentical hematopoietic stem-cell transplantation [J].

Ball, Lynne M. ;

Bernardo, Maria Ester ;

Roelofs, Helene ;

Lankester, Arjan ;

Cometa, Angela ;

Egeler, R. Maarten ;

Locatelli, Franco ;

Fibbe, Willem E. .

BLOOD, 2007, 110 (07) :2764-2767

[7]

Kinetics of engraftment in patients with hematologic malignancies given allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning [J].

Baron, F ;

Baker, JE ;

Storb, R ;

Gooley, TA ;

Sandmaier, BM ;

Maris, MB ;

Maloney, DG ;

Heimfeld, S ;

Oparin, D ;

Zellmer, E ;

Radich, JP ;

Grumet, FC ;

Blume, KG ;

Chauncey, TR ;

Little, MT .

BLOOD, 2004, 104 (08) :2254-2262

[8]

Cotransplantation of Mesenchymal Stem Cells Might Prevent Death from Graft-versus-Host Disease (GVHD) without Abrogating Graft-versus-Tumor Effects after HLA-Mismatched Allogeneic Transplantation following Nonmyeloablative Conditioning [J].

Baron, Frederic ;

Lechanteur, Chantal ;

Willems, Evelyne ;

Bruck, France ;

Baudoux, Etienne ;

Seidel, Laurence ;

Vanbellinghen, Jean-Francois ;

Hafraoui, Kaoutar ;

Lejeune, Marie ;

Gothot, Andre ;

Fillet, Georges ;

Beguin, Yves .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2010, 16 (06) :838-847

[9]

Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo [J].

Bartholomew, A ;

Sturgeon, C ;

Siatskas, M ;

Ferrer, K ;

McIntosh, K ;

Patil, S ;

Hardy, W ;

Devine, S ;

Ucker, D ;

Deans, R ;

Moseley, A ;

Hoffman, R .

EXPERIMENTAL HEMATOLOGY, 2002, 30 (01) :42-48

[10]

Human mesenchymal stem cells induce T cell anergy and downregulate T cell allo-responses via the TH2 pathway: Relevance to tissue engineering human heart valves [J].

Batten, Puspa ;

Sarathchandra, Padmini ;

Antoniw, Joseph W. ;

Tay, Szun Szun ;

Lowdell, Mark W. ;

Taylor, Patricia M. ;

Yacoub, Magdi H. .

TISSUE ENGINEERING, 2006, 12 (08) :2263-2273

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