Titanocene-based method for indole synthesis

被引：54

作者：

Aoki, K ^{[1
]}

Peat, AJ ^{[1
]}

Buchwald, SL ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1998年 / 120卷 / 13期

关键词：

D O I：

10.1021/ja972281p

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new approach for the construction of indoles employing the air-and moisture-stable reagent Cp2TiCl2 is described. The key steps involved are (1) the intermolecular insertion reactions of an olefin and a titanocene-stabilized benzyne complex and (2) the Pd-catalyzed aryl amination reaction. The simplicity and availability of the requisite starting materials give the method a broad scope for the preparation of polysubstituted indoles.

引用

页码：3068 / 3073

页数：6

共 36 条

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[2]

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