A new gene for asthma: would you ADAM and Eve it?

被引：20

作者：

Cookson, W ^{[1
]}

机构：

[1] Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England

来源：

TRENDS IN GENETICS | 2003年 / 19卷 / 04期

关键词：

D O I：

10.1016/S0168-9525(03)00025-8

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Recently, a novel gene was reported to underlie asthma. Linkage to the short arm of chromosome 20 in a genome screen was followed by positive tests of association that centre on the gene for a membrane-anchored zinc-dependent metalloproteinase known as ADAM33. The domain structure of the ADAM33 protein gives capabilities of proteolysis, adhesion, cell fusion and intracellular signalling. Although its function is at present unknown, these potential actions of ADAM33 provide many possibilities for further research.

引用

页码：169 / 172

页数：4

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