Regular exercise is beneficial to a mouse model of amyotrophic lateral sclerosis

被引：131

作者：

Kirkinezos, IG

Hernandez, D

Bradley, WG

Moraes, CT

机构：

[1] Univ Miami, Sch Med, Dept Cell Biol & Anat, Miami, FL 33136 USA

[2] Univ Miami, Sch Med, Dept Neurol, Miami, FL 33136 USA

来源：

ANNALS OF NEUROLOGY | 2003年 / 53卷 / 06期

关键词：

D O I：

10.1002/ana.10597

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We tested whether a regular exercise regimen was associated with a change in the life span of G93A-SOD1 transgenic mice, a model of familial AILS. Regular treadmill running for 10 weeks led to a significant increase in the life span of G93A-SOD1 mice. The effect was stronger in male mice, whereas there was only a trend between exercised and sedentary female G93A-SOD1 mice. The data suggest that regular exercise has a beneficial effect on the progression of ALS.

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页码：804 / 807

页数：4

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