The product of a thyroid hormone-responsive gene interacts with thyroid hormone receptors

被引：109

作者：

Thompson, CC

Bottcher, MC

机构：

[1] Department of Neuroscience, Johns Hopkins Univ. Sch. of Medicine, Kennedy Krieger Institute, Baltimore, MD 21205

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1997年 / 94卷 / 16期

关键词：

D O I：

10.1073/pnas.94.16.8527

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Thyroid hormone is a critical mediator of central nervous system (CNS) development, acting through nuclear receptors to modulate the expression of specific genes. Transcription of the rat hairless (hr) gene Is highly upregulated by thyroid hormone in the developing CNS; we show here that hr Is directly induced by thyroid hormone, By identifying proteins that interact with the hr gene product (Hr), we find that Hr interacts directly and specifically with thyroid hormone receptor (TR)-the same protein that regulates its expression. Unlike previously described receptor-interacting factors, Hr associates with TR and not with retinoic acid receptors (RAR, RXR). Hr can act as a transcriptional repressor, suggesting that its interaction with TR Is part of a novel autoregulatory mechanism.

引用

页码：8527 / 8532

页数：6

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