Modulation of the phenotypic diversity of sickle cell anemia

被引：26

作者：

Steinberg, MH

机构：

[1] Veterans Affairs Medical Center, Department of Medicine, Univ. of Mississippi Sch. of Med., Jackson

来源：

HEMOGLOBIN | 1996年 / 20卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.3109/03630269609027906

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sickle cell anemia is noted for being phenotypically heterogeneous. This suggests that there are genetic influences that moderate the effects of the sickle hemoglobin mutation. In this review I focus on genetically determined modulation of hemoglobin concentration and fetal hemoglobin levels. Each of these variables has important influences upon sickle hemoglobin polymerization and the resulting pathophysiology.

引用

页码：1 / 19

页数：19

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