Thrombin generation: the functional role of alpha-2-macroglobulin and influence of developmental haemostasis

被引：35

作者：

Ignjatovic, V.

Greenway, A.

Summerhayes, R.

Monagle, P.

机构：

[1] Royal Childrens Hosp, Dept Clin Haematol, Melbourne, Vic, Australia

[2] Univ Melbourne, Dept Pathol, Melbourne, Vic, Australia

[3] Murdoch Chidrens Res Inst, Melbourne, Vic, Australia

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2007年 / 138卷 / 03期

关键词：

thrombin generation; children; alpha-2-macroglobulin;

D O I：

10.1111/j.1365-2141.2007.06663.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Currently available chromogenic and fluorogenic substrates for endogenous thrombin potential (ETP) measurement are cleaved by both free (active) and alpha-2-macroglobulin-bound (inactive) thrombin, leading to an overestimation of ETP. Commercial methods for ETP measurement determine this using a mathematical algorithm, which assumes the contribution of alpha-2-macroglobulin to the ETP. This limits application of such methods to populations where variation in alpha-2-macroglobulin concentrations is observed, primarily children. This study examined the contribution of alpha-2-macroglobulin-bound thrombin to the ETP measurement in neonates, children and adults, to determine whether automated methods are appropriate for use in neonates and children.

引用

页码：366 / 368

页数：3

共 11 条

[1] The thrombogram in rare inherited coagulation disorders:: Its relation to clinical bleeding [J].