Cancer cachexia syndrome in head and neck cancer patients: Part I. Diagnosis, impact on quality of life and survival, and treatment

被引：112

作者：

Couch, Marion ^{[1
]}

Lai, Victor

Cannon, Trinitia

Guttridge, Denis

Zanation, Adam

George, Jonathan

Hayes, D. Neil

Zeisel, Steven

Shores, Carol

机构：

[1] Univ N Carolina, Sch Med, Dept Otolaryngol Head & Neck Surg, Neurosci Hosp G0412, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Sch Med, Verne S Caviness Gen Clin Res Ctr, Neurosci Hosp G0412, Chapel Hill, NC 27599 USA

[3] Ohio State Univ, Div Human Genet, Dept Mol Virol Immunol & Med Genet, Arthur G James Comprehens Canc Ctr, Columbus, OH 43210 USA

[4] Univ N Carolina, Sch Med, Dept Internal Med, Div Med Oncol, Chapel Hill, NC USA

[5] Univ N Carolina, Sch Med, Dept Pediat, Sch Publ Hlth,Dept Nutr, Chapel Hill, NC USA

[6] Univ N Carolina, Sch Med, Lineberger Comprehens Canc Ctr, Chapel Hill, NC USA

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2007年 / 29卷 / 04期

关键词：

cancer cachexia and anorexia; muscle wasting; weight loss; NF-KAPPA-B; WEIGHT-LOSS; PANCREATIC-CANCER; ANOREXIA-CACHEXIA; SKELETAL-MUSCLE; EICOSAPENTAENOIC ACID; MEGESTROL-ACETATE; ORAL SUPPLEMENT; PALLIATIVE CARE; NEUROPEPTIDE-Y;

D O I：

10.1002/hed.20447

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background. Cancer cachexia is a debilitating, wasting condition that affects many cancer patients, including those with head and neck cancer. The overall incidence of cancer cachexia is quite high for some types of cancer, and cachexia will be the main cause of death for more than 20% of all cancer patients. This syndrome uniquely challenges patients with head and neck cancer. This article outlines the diagnosis of cancer cachexa, reviews its impact on patient quality of life (QOL) and survival, and updates the reader on potential therapies that may suppress it.

引用

页码：401 / 411

页数：11

共 58 条

[1] Cancer cachexia is regulated by selective targeting of skeletal muscle gene products [J].

Acharyya, S ;

Ladner, KJ ;

Nelsen, LL ;

Damrauer, J ;

Reiser, PJ ;

Swoap, S ;

Guttridge, DC .

JOURNAL OF CLINICAL INVESTIGATION, 2004, 114 (03) :370-378

[2] Why do patients with weight loss have a worse outcome when undergoing chemotherapy for gastrointestinal malignancies? [J].

Andreyev, HJN ;

Norman, AR ;

Oates, J ;

Cunningham, D .

EUROPEAN JOURNAL OF CANCER, 1998, 34 (04) :503-509

[3] The effect of an oral nutritional supplement enriched with fish oil on weight loss in patients with pancreatic cancer [J].

Barber, MD ;

Ross, JA ;

Voss, AC ;

Tisdale, MJ ;

Fearon, KCH .

BRITISH JOURNAL OF CANCER, 1999, 81 (01) :80-86

[4] Nutrition intervention improves outcomes in patients with cancer cachexia receiving chemotherapy - a pilot study [J].

Bauer, JD ;

Capra, S .

SUPPORTIVE CARE IN CANCER, 2005, 13 (04) :270-274

[5] ABC of palliative care - Anorexia, cachexia, and nutrition [J].

Bruera, E .

BRITISH MEDICAL JOURNAL, 1997, 315 (7117) :1219-1222

[6] Effect of fish oil on appetite and other symptoms in patients with advanced cancer and anorexia/cachexia: A double-blind, placebo-controlled study [J].

Bruera, E ;

Strasser, F ;

Palmer, JL ;

Willey, J ;

Calder, K ;

Amyotte, G ;

Baracos, V .

JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (01) :129-134

[7] ROLE OF MEGESTROL-ACETATE IN THE TREATMENT OF CACHEXIA IN PATIENTS WITH HEAD AND NECK-CANCER [J].

BUNTZEL, J ;

KUTTNER, K .

LARYNGO-RHINO-OTOLOGIE, 1995, 74 (08) :504-507

[8] Assessment of feeding response of tumor-bearing rats to hypothalamic injection and infusion of neuropeptide Y [J].

Chance, WT ;

Balasubramaniam, A ;

Thompson, H ;

Mohapatra, B ;

Ramo, J ;

Fischer, JE .

PEPTIDES, 1996, 17 (05) :797-801

[9] Inhibition of cyclooxygenase-2 by celecoxib reverses tumor-induced wasting [J].

Davis, TW ;

Zweifel, BS ;

O'Neal, JM ;

Heuvelman, DM ;

Abegg, AL ;

Hendrich, TO ;

Masferrer, JL .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2004, 308 (03) :929-934

[10] Standards, Options and Recommendations for the use of appetite stimulants in oncology (2000) [J].

Desport, JC ;

Gory-Delabaere, G ;

Blanc-Vincent, MP ;

Bachmann, P ;

Béal, J ;

Benamouzig, R ;

Colomb, V ;

Kere, D ;

Melchior, JC ;

Nitenberg, G ;

Raynard, B ;

Schneider, S ;

Senesse, P .

BRITISH JOURNAL OF CANCER, 2003, 89 (Suppl 1) :S98-S100

← 1 2 3 4 5 6 →