A base-catalyzed solution-phase parallel synthesis of substituted vinylic benzamides from 3-amino-2-cyclohexanones

被引：12

作者：

Anderson, AJ

Nicholson, JM

Bakare, O

Butcher, RJ

Scott, KR ^{[1
]}

机构：

[1] Howard Univ, Sch Pharm, Dept Pharmaceut Sci, Washington, DC 20059 USA

[2] Howard Univ, Grad Sch, Dept Chem, Washington, DC 20059 USA

来源：

JOURNAL OF COMBINATORIAL CHEMISTRY | 2004年 / 6卷 / 06期

关键词：

D O I：

10.1021/cc0498837

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

An improved method for the synthesis of benzamides from 3-amino-2-cyclohexenones is presented. Using sodium hydride, a base-catalyzed N-benzoylation provided significantly higher yields (71-79%) for the reported compounds. This novel protocol was applied in the solution-phase parallel synthesis of a 12-member library of vinylic benzamide derivatives of 3-amino-2-cyclohexenones in 63-90% yield, using a Radley's Carousel Reaction Station.

引用

收藏

页码：950 / 954

页数：5

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