Parasite plastids: maintenance and functions

被引：30

作者：

Wilson, RJM ^{[1
]}

Rangachari, K ^{[1
]}

Saldanha, JW ^{[1
]}

Rickman, L ^{[1
]}

Buxton, RS ^{[1
]}

Eccleston, JF ^{[1
]}

机构：

[1] Natl Inst Med Res, London NW7 1AA, England

来源：

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES | 2003年 / 358卷 / 1429期

基金：

英国医学研究理事会;

关键词：

apicomplexa; plastid function; SufB; SufC;

D O I：

10.1098/rstb.2002.1187

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Malaria and related parasites retain a vestigial, but biosynthetically active, plastic. organelle acquired far back in evolution from a red algal cell. The organelle appears to be essential for parasite transmission from cell to cell and carries the smallest known plastic. genome. Why has this genome been retained? The genes it carries seem to be dedicated to the expression of just two 'housekeeping' genes. We speculate that one of these, called ycf24 in plants and sufB in bacteria, is tied to an essential 'dark' reaction of the organelle-fatty acid biosynthesis. 'Ball-park' clues to the function of bacterial suf genes have emerged only recently and point to the areas of iron homeostasis, [Fe-S] cluster formation and oxidative stress. We present experimental evidence for a physical interaction between SufB and its putative partner SufC (ycf16). In both malaria and plants, SufC is encoded in the nucleus and specifies an ATPase that is imported into the plastid.

引用

页码：155 / 162

页数：8

共 59 条

[1] REDOX CONTROL OF TRANSCRIPTION - SENSORS, RESPONSE REGULATORS, ACTIVATORS AND REPRESSORS [J].