Matrix effects on the bioavailability of resveratrol in humans

被引：64

作者：

Ortuno, Jordi ^{[1
]}

Covas, Maria-Isabel ^{[2
,7
]}

Farre, Magi ^{[1
,3
]}

Pujadas, Mitona ^{[1
,7
]}

Fito, Montserrat ^{[2
,7
]}

Khymenets, Olha ^{[1
,7
]}

Andres-Lacueva, Cristina ^{[4
]}

Roset, Pere ^{[1
,3
]}

Joglar, Jesus ^{[5
]}

Lamuela-Raventos, Rosa M. ^{[4
]}

de la Torre, Rafael ^{[1
,6
,7
]}

机构：

[1] Hosp del Mar, IMIM, Neuropsychopharmacol Res Program, Human Pharmacol & Clin Neurosci Res Grp, Barcelona 08003, Spain

[2] Hosp del Mar, IMIM, Inflammatory & Cardiovasc Disorders Res Program, Oxidat Stress & Nutr Res Grp, Barcelona 08003, Spain

[3] Univ Autonoma Barcelona, UDIMAS, E-08193 Barcelona, Spain

[4] Univ Barcelona, Fac Farm, Dept Nutr & Bromatol, XaRTA,INSA, E-08028 Barcelona, Spain

[5] CSIC, IIQAB, Dept Biol Organ Chem, ES-08034 Barcelona, Spain

[6] Univ Pompeu Fabra, CEXS, Barcelona 08003, Spain

[7] Hosp Clin Univ Santiago Compostela, CIBEROBN, CIBER Fisiopatol Obesidad & Nutr CB06 03, Santiago De Compostela 15706, Spain

来源：

FOOD CHEMISTRY | 2010年 / 120卷 / 04期

关键词：

Resveratrol; Grape products; Wine; Grape juice; Resveratrol disposition; TRANS-RESVERATROL; MEDITERRANEAN DIET; METABOLITES; WINE; IDENTIFICATION; QUANTIFICATION; POLYPHENOLS; PERFORMANCE; ABSORPTION;

D O I：

10.1016/j.foodchem.2009.11.032

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

The pharmacokinetics of resveratrol in I I healthy male volunteers has been assessed in a randomized, crossover, controlled clinical trial after the administration of three grape products: red wine (250 mL). grape juice (1/L), or tablets (red wine extracts enriched with trans-resveratrol). Doses of trans-resveratrol independently of the product administered, were about 14 mu g/kg. Biological samples were collected and analysed by capillary gas chromatography-mass spectrometry. cis-Resveratrol, trans-resveratrol and dihydroresveratrol were determined in plasma and urine. Plasma concentration of trans-resveratrol after hydrolysis increased as a response to all grape products and that of cis-resveratrol after wine and grape juice. Free forms of these phenolic compounds were deemed undetectable in plasma. Despite similar trans-resveratrol doses being administered, its bioavailability from wine and grape juice was 6-fold higher, than that from tablets. Resveratrol was better absorbed from natural grape products than from tablets, pointing out the importance of the matrix in its bioavailability. (C) 2009 Elsevier Ltd. All rights reserved

引用

页码：1123 / 1130

页数：8

共 29 条

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