Cardiac repair with autologous bone marrow stem cells

被引：7

作者：

Futterman, LG ^{[1
]}

Lemberg, L ^{[1
]}

机构：

[1] Univ Miami, Sch Med, Div Cardiol, Dept Med, Miami, FL 33101 USA

来源：

AMERICAN JOURNAL OF CRITICAL CARE | 2004年 / 13卷 / 06期

关键词：

D O I：

10.4037/ajcc2004.13.6.512

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

All adults have stem cells in their body that can act like embryonic stem cells when given an appropriate stimulus. When VEGF is given, the bone marrow is stimulated to release stem cells, which grow new coronary arteries and also replenish damaged or dead cardiomyocytes. Transplanting autologous bone marrow stem cells into coronary arteries reduced infarct size, improved the prognosis following an acute MI and in patients with chronic congestive heart failure. Since patients are the source of their own stem cells, there would be a ready supply, with no rejection or immunological issues, and political debate on stem cell research would end. It is worth noting that statin therapy stimulates mobilization of EPCs, which repair damaged or dead myocardial cells and stimulate growth of new coronary arteries.

引用

页码：512 / 518

页数：7

共 24 条

[1]

Cowan CA, 2004, NEW ENGL J MED, V350, P1353, DOI 10.1056/NEJMsr040330

[2] Bone marrow-derived cardiomyocytes are present in adult human heart - A study of gender-mismatched bone marrow transplantation patients [J].

Deb, A ;

Wang, SH ;

Skelding, KA ;

Miller, D ;

Simper, D ;

Caplice, NM .

CIRCULATION, 2003, 107 (09) :1247-1249

[3] Regulation of the vascular extracellular superoxide dismutase by nitric oxide and exercise training [J].

Fukai, T ;

Siegfried, MR ;

Ushio-Fukai, M ;

Cheng, Y ;

Kojda, G ;

Harrison, DG .

JOURNAL OF CLINICAL INVESTIGATION, 2000, 105 (11) :1631-1639

[4] New human embryonic stem-cell lines - More is better [J].

Gearhart, J .

NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (13) :1275-1276

[5] Transplantation of cells for cardiac repair [J].

Hassink, RJ ;

de la Rivière, AB ;

Mummery, CL ;

Doevendans, PA .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2003, 41 (05) :711-717

[6] Profoundly reduced neovascularization capacity of bone marrow mononuclear cells derived from patients with chronic ischemic heart disease [J].

Heeschen, C ;

Lehmann, R ;

Honold, J ;

Assmus, B ;

Aicher, A ;

Walter, DH ;

Martin, H ;

Zeiher, AM ;

Dimmeler, S .

CIRCULATION, 2004, 109 (13) :1615-1622

[7] Circulating endothelial progenitor cells, vascular function, and cardiovascular risk [J].

Hill, JM ;

Zalos, G ;

Halcox, JPJ ;

Schenke, WH ;

Waclawiw, MA ;

Quyyumi, AA ;

Finkel, T .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (07) :593-600

[8] Local delivery of marrow-derived stromal cells augments collateral perfusion through paracrine mechanisms [J].

Kinnaird, T ;

Stabile, E ;

Burnett, MS ;

Shou, M ;

Lee, CW ;

Barr, S ;

Fuchs, S ;

Epstein, SE .

CIRCULATION, 2004, 109 (12) :1543-1549

[9] Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function [J].

Kocher, AA ;

Schuster, MD ;

Szabolcs, MJ ;

Takuma, S ;

Burkhoff, D ;

Wang, J ;

Homma, S ;

Edwards, NM ;

Itescu, S .

NATURE MEDICINE, 2001, 7 (04) :430-436

[10] Physical training increases endothelial progenitor cells, inhibits neointima formation, and enhances angiogenesis [J].

Laufs, U ;

Werner, N ;

Link, A ;

Endres, M ;

Wassmann, S ;

Jürgens, K ;

Miche, E ;

Böhm, M ;

Nickenig, G .

CIRCULATION, 2004, 109 (02) :220-226

← 1 2 3 →