Apoptosis - An endonuclease at last

被引：46

作者：

Wyllie, A ^{[1
]}

机构：

[1] Univ Edinburgh, Dept Pathol, Sir Alastair Currie CRC Labs, Edinburgh EH4 2XU, Midlothian, Scotland

来源：

NATURE | 1998年 / 391卷 / 6662期

关键词：

D O I：

10.1038/34040

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

One of the main clues that apoptosis is a ‘programmed’ cell death is the production of ‘chromatin ladders’ — digestion of DNA into regularly sized fragments. The nuclease responsible for this cleavage has now been identified. Found as an inactive form within the cytoplasm, this nuclease is activated by caspase-3 digestion, earning it the name caspase-activated DNAse (CAD). The same group has also identified a protein that binds to, and inactivates, CAD, and the overall picture seems to be that this protein, ICAD (for inhibitor of CAD), releases CAD after caspase-3 digestion.

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页码：20 / 21

页数：2

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