Proteolytic cleavage of CD25, the α subunit of the human T cell interleukin 2 receptor, by Der p 1, a major mite allergen with cysteine protease activity

被引:211
作者
Schulz, O [1 ]
Sewell, HF [1 ]
Shakib, F [1 ]
机构
[1] Univ Nottingham, Queens Med Ctr, Fac Med & Hlth Sci, Div Mol & Clin Immunol, Nottingham NG7 2UH, England
关键词
D O I
10.1084/jem.187.2.271
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Recent reports have indicated that the cysteine protease activity of Der p 1 may play a significant role in its ability to elicit IgE antibody responses, mainly through cleavage of membrane CD23 on B cells and interleukin (IL)-4 synthesis and secretion from mast cells and basophils. Here we demonstrate for the first time that Der p 1 also cleaves the alpha subunit of the IL-2 receptor (IL-2R or CD25) from the surface of human peripheral blood T cells and, as a result, these cells show markedly diminished proliferation and interferon gamma secretion in response to potent stimulation by anti-CD3 antibody. Given that the IL-2R is pivotal for the propagation of Th1 cells, its cleavage by Der p 1 may consequently bias thr immune response towards Th2 cells, thereby creating an allergic microenvironment.
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页码:271 / 275
页数:5
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