The contribution of HPV18 to cervical cancer is underestimated using high-grade CIN as a measure of screening efficiency

被引：20

作者：

Bulk, S.

Berkhof, J.

Rozendaal, L.

Daalmeijer, N. C. Fransen

Gok, M.

de Schipper, F. A.

van Kemenade, F. J.

Snijders, P. J. F.

Meijer, C. J. L. M.

机构：

[1] Vrije Univ Amsterdam, Med Ctr, Dept Pathol, NL-1007 MB Amsterdam, Netherlands

[2] Vrije Univ Amsterdam, Med Ctr, Dept Clin Epidemiol & Biostat, NL-1007 MB Amsterdam, Netherlands

[3] Hosp Walcheren, Dept Obstet & Gynecol, NL-4380 DD Vlissingen, Netherlands

来源：

BRITISH JOURNAL OF CANCER | 2007年 / 96卷 / 08期

关键词：

cervical intraepithelial neoplasia; squamous cell carcinoma; human papillomavirus; epidemiology; PALGA;

D O I：

10.1038/sj.bjc.6603693

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In one geographical area, 14 high-risk human papillomavirus types in cervical intraepithelial neoplasia (CIN2/3; n=139) and cervical squamous cell carcinoma (SCC; n=84) were analysed. HPV18 was more prevalent in SCC than CIN2/3 (OR 9.8; 95% confidence interval: 2.5-39). Other high-risk types prevalences corresponded in CIN2/3 and SCC. Evaluations using CIN2/3 as a measure of efficiency underestimate the contribution of HPV18 to SCC.

引用

收藏

页码：1234 / 1236

页数：3

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