GA binding protein regulates interleukin 7 receptor α-chain gene expression in T cells

被引：116

作者：

Xue, HH

Bollenbacher, J

Rovella, V

Tripuraneni, R

Du, YB

Liu, CY

Williams, A

McCoy, JP

Leonard, WJ

机构：

[1] NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA

[2] NHLBI, Transgenic Facil, NIH, Bethesda, MD 20892 USA

[3] NHLBI, Flow Cytometry Core Facil, NIH, Bethesda, MD 20892 USA

来源：

NATURE IMMUNOLOGY | 2004年 / 5卷 / 10期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/ni1117

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The interleukin 7 receptor alpha-chain (IL-7Ralpha) is essential for T cell development in both humans and mice and for B cell development in mice. Whereas the transcription factor PU. 1 regulates IL-7Ra expression in mouse pro-B cells via a GGAA motif, we demonstrate here that GA binding protein (GABP) bound to this site and was essential in the regulation of IL-7Ralpha expression in T cells, where PU. 1 is not expressed. Moreover, IL-7Ralpha expression was diminished substantially in thymocytes but was normal on B220(+) fetal liver cells from mouse embryos with diminished expression of GABPalpha. Thus, GABP is essential for the regulation of IL-7Ralpha expression in T cells, and the differential regulation of IL-7Ralpha in distinct lymphoid lineages is achieved at least in part by differential recruitment of factors to the same GGAA motif.

引用

页码：1036 / 1044

页数：9

共 47 条

[1] Two distinct pathways of positive selection for thymocytes [J].