CD4+ T cells from Copolymer-1 immunized mice protect dopaminergic neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease

被引：76

作者：

Laurie, Chad

Reynolds, Ashley

Coskun, Ozlem

Bowman, Erik

Gendelman, Howard E.

Mosley, R. Lee

机构：

[1] Univ Nebraska, Med Ctr, Dept Pharm & Expt Neurosci, Ctr Neurovirol & Neurodegenerat Disorders, Omaha, NE USA

[2] Univ Nebraska, Med Ctr, Dept Internal Med, Omaha, NE USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2007年 / 183卷 / 1-2期

关键词：

copolymer-1; MPTP; immunomodulation; neuroprotection; CD4(+) T cells; Parkinson's disease;

D O I：

10.1016/j.jneuroim.2006.11.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Adoptive transfer of lymphoid cells from Copolymer 1 (Cop-1) immunized mice leads to T cell accumulation within the substantia nigra, modulation of microglial responses, upregulation of glial cell derived neurotrophic factor, and protection of the nigrostriatum following 1-methyl-4-phenyl- 1,2,3,6-tetrahydropyridine (MPTP) intoxication. We now demonstrate that T cells isolated from lymph nodes and spleens of Cop-1 immunized animals protect the nigrostriatal system from MPTP-induced neurodegeneration in a dose-dependent manner. CD4+ T cells elicited the most significant neuroprotective response while high titers of anti-Cop-1 antibodies showed no effect. These data further support the use of immunomodulatory strategies for Parkinson's disease. (c) 2006 Published by Elsevier B.V.

引用

页码：60 / 68

页数：9

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