How should we describe the radiobiologic effect of extracranial stereotactic radiosurgery: Equivalent uniform dose or tumor control probability?

被引：39

作者：

Kavanagh, BD ^{[1
]}

Timmerman, RD

Benedict, SH

Wu, Q

Schefter, TE

Stuhr, K

McCourt, S

Newman, F

Cardinale, RM

Gaspar, LE

机构：

[1] Univ Colorado, Hlth Sci Ctr, Dept Radiat Oncol, Aurora, CO 80010 USA

[2] Indiana Univ, Dept Radiat Oncol, Bloomington, IN 47405 USA

[3] Virginia Commonwealth Univ, Med Coll Virginia, Dept Radiat Oncol, Richmond, VA 23298 USA

来源：

MEDICAL PHYSICS | 2003年 / 30卷 / 03期

关键词：

extracranial; stereotactic; radiosurgery; EUD; TCP;

D O I：

10.1118/1.1543571

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Extracranial stereotactic radiosurgery (ESR) is now undergoing clinical investigation at numerous institutions as a treatment for solitary malignant lesions. Because there is no standard ESR technique, the same minimum dose might be applied through widely variable target dose-volume histograms. For multicenter trials of ESR or interinstitutional comparisons, a reliable index of radiobiological dose equivalency might facilitate the evaluation of dose-response relationships. Equivalent uniform dose (EUD) and tumor control probability (TCP) were considered for this application. While EUD appears more robust for the prospective description of ESR, TCP is expected to remain more valuable for a post hoc estimation of radiosensitivity parameters. (C) 2003 American Association of Physicists in Medicine.

引用

页码：321 / 324

页数：4

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