Molecular characterization of influenza B viruses circulating in northern Italy during the 2001-2002 epidemic season

被引:37
作者
Ansaldi, F
D'Agaro, P
de Florentiis, D
Puzelli, S
Lin, YP
Gregory, V
Bennett, M
Donatelli, I
Gasparini, R
Crovari, P
Hay, A
Campello, C
机构
[1] Univ Trieste, Dept Publ Med Sci, IRCCS Burlo Garofolo, UCO Hyg & Prevent Med, I-34137 Trieste, Italy
[2] Ist Super Sanita, Natl Influenza Ctr, I-00161 Rome, Italy
[3] WHO, Influenza Collaborating Ctr, Natl Inst Med Res, London, England
[4] Univ Genoa, Dept Hlth Sci, I-16126 Genoa, Italy
关键词
influenza B virus; haemagglutinin; molecular epidemiology; sequence analysis;
D O I
10.1002/jmv.10418
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
During the 2001-2002 influenza season, virological surveillance highlighted the predominant circulation of B viruses (86% of isolates) in Italy, in contrast to many other countries in Europe and North America where AH3N2 viruses were isolated most frequently, and in contrast to the infrequent isolation of B viruses in Italy during the previous two years. Associated with this predominance of influenza B was the re-emergence of B/Victoria/2/87-lineage viruses, closely related to B viruses prevalent during the 1980s, which are distinct antigenically and genetically from circulating B/Sichuan/379/99-like viruses of the B/Yamagata/16/88 lineage, which predominated in most parts of the world during the last 10 years. Ninety-four viruses isolated in two regions of northern Italy were characterized, 50 by direct sequencing of haemagglutinin (HA). Viruses of both Victoria and Yamagata lineages co-circulated throughout the 12 weeks of the influenza season. The HAs of the Yamagata-lineage viruses were heterogeneous and comprised two sublineages, represented by B/Sichuan/379/99 and B/Harbin/7/94, whereas the Victoria-lineage viruses were more homogeneous and closely related to B/Hong Kong/330/01, the current prototype vaccine strain. The antigenic and genetic characteristics of the viruses correlated with certain epidemiological features. In particular, the low age (< 14 years) of individuals infected with B/Hong Kong/330/01-like viruses is likely to reflect the greater susceptibility of the youngest cohort, due to lack of previous exposure to Victoria-lineage viruses, and is consistent with the conclusion that vaccination with a B/Sichuan/379/99-like virus would give poor protection against infection with B/Hong Kong/330/01-like (Victoria-lineage) viruses. (C) 2003 Wiley-Liss, Inc.
引用
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页码:463 / 469
页数:7
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