A conserved family of enzymes that phosphorylate inositol hexakisphosphate

被引：193

作者：

Mulugu, Sashidhar

Bai, Wenli

Fridy, Peter C.

Bastidas, Robert J.

Otto, James C.

Dollins, D. Eric

Haystead, Timothy A.

Ribeiro, Anthony A.

York, John D.

机构：

[1] Duke Univ, Med Ctr, Howard Hughes Med Inst, Dept Pharmacol & Canc Biol, Durham, NC 27710 USA

[2] Duke Univ, Med Ctr, Dept Biochem, NMR Ctr, Durham, NC 27710 USA

来源：

SCIENCE | 2007年 / 316卷 / 5821期

关键词：

MESSENGER-RNA EXPORT; ARP2/3; COMPLEX; SACCHAROMYCES-CEREVISIAE; ACTIN; PYROPHOSPHATES; PHOSPHATES; TETRAKISPHOSPHATE; POLYPHOSPHATES; DICTYOSTELIUM; METABOLISM;

D O I：

10.1126/science.1139099

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Inositol pyrophosphates are a diverse group of high-energy signaling molecules whose cellular roles remain an active area of study. We report a previously uncharacterized class of inositol pyrophosphate synthase and find it is identical to yeast Vip1 and Asp1 proteins, regulators of actin-related protein-2/3 (ARP 2/3) complexes. Vip1 and Asp1 acted as enzymes that encode inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase activities. Alterations in kinase activity led to defects in cell growth, morphology, and interactions with ARP complex members. The functionality of Asp1 and Vip1 may provide cells with increased signaling capacity through metabolism of IP6.

引用

页码：106 / 109

页数：4

共 30 条

[1] Inositol pyrophosphates: metabolism and signaling [J].