Deep magnetic capture of magnetically loaded cells for spatially targeted therapeutics

被引：47

作者：

Huang, Zheyong ^{[1
]}

Pei, Ning ^{[2
]}

Wang, Yanyan ^{[3
]}

Xie, Xinxing ^{[1
]}

Sun, Aijun ^{[1
]}

Shen, Li ^{[1
]}

Zhang, Shuning ^{[1
]}

Liu, Xuebo ^{[1
]}

Zou, Yunzeng ^{[1
]}

Qian, Juying ^{[1
]}

Ge, Junbo ^{[1
]}

机构：

[1] Fudan Univ, Zhongshan Hosp, Shanghai Inst Cardiovasc Dis, Shanghai 200032, Peoples R China

[2] Shanghai Univ, Coll Sci, Shanghai 200444, Peoples R China

[3] Fudan Univ, Zhongshan Hosp, Dept Internal Med, Shanghai 200032, Peoples R China

来源：

BIOMATERIALS | 2010年 / 31卷 / 08期

关键词：

Magnetism; In vitro test; Mesenchcymal stem cell; Nanoparticle; ENDOTHELIAL PROGENITOR CELLS; ACUTE MYOCARDIAL-INFARCTION; THERAPY; ANGIOGRAPHY; NANOPARTICLES; METAANALYSIS; ENGRAFTMENT; PERFUSION; DELIVERY; RESOVIST;

D O I：

10.1016/j.biomaterials.2009.11.062

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Magnetic targeting has recently demonstrated potential in promoting magnetically loaded cell delivery to target lesion, but its application is limited by magnetic attenuation. For deep magnetic capture of cells for spatial targeting therapeutics, we designed a magnetic pole, in which the magnetic field density can be focused at a distance from the pole. As flowing through a tube served as a model of blood vessels, the magnetically loaded mesenchymal stem cells (MagMSCs) were highly enriched at the site distance from the magnetic pole. The cell capture efficiency was positively influenced by the magnetic flux density, and inversely influenced by the flow velocity, and well-fitted with the deductive value by theoretical considerations. It appeared to us that the spatially-focused property of the magnetic apparatus promises a new deep targeting strategy to promote homing and engraftment for cellular therapy. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：2130 / 2140

页数：11

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