Ginsenoside Rb1 protects against damage to the spiral ganglion cells after cochlear ischemia

被引：51

作者：

Fujita, Kensuke

Hakuba, Nobuhiro ^{[1
]}

Hata, Ryuji

Morizane, Isao

Yoshida, Tadashi

Shudou, Masachika

Sakanaka, Masahiro

Gyo, Kiyofumi

机构：

[1] Ehime Univ, Sch Med, Dept Otolaryngol, Matsuyama, Ehime 790, Japan

[2] Ehime Univ, Sch Med, Div Funct Histol, Matsuyama, Ehime 790, Japan

[3] Ehime Univ, Sch Med, Ctr Res Lab, Matsuyama, Ehime 790, Japan

来源：

NEUROSCIENCE LETTERS | 2007年 / 415卷 / 02期

关键词：

transient cochlear ischemia; spiral ganglion cells; ginsenoside Rb1; TUNEL staining; Bcl-xL protein;

D O I：

10.1016/j.neulet.2007.01.005

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of transient cochlear ischemia on spiral ganglion cells (SGCs) were studied in Mongolian gerbils. Ischemic insult was induced by occluding the bilateral vertebral arteries of gerbils for 15 min. Seven days after ischemia, the percentage of SGCs decreased to 67.5% from the preischemic baseline in the basal turn. Evaluation with immunohistochemical staining showed TUNEL-positive reactions in the SGCs with fragmented nuclei. In addition, we investigated the protective effects of ginsenoside Rb1 (gRb1) against ischemic injury to SGCs. Seven days after ischemia, the auditory brainstem response threshold shift was significantly reduced and the percentage of SGCs decreased to 90.2% from the preischemic baseline in the basal turn in the gRb1-treated group. These findings suggest that Rb1 prevented hearing loss caused by ischemic injury to SGCs in Mongolian gerbils. (c) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：113 / 117

页数：5

共 18 条

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