Protein C deficiency related to valproic acid therapy: A possible association with childhood stroke

被引：14

作者：

Gruppo, R

DeGrauw, A

Fogelson, H

Glauser, T

Balasa, V

Gartside, P

机构：

[1] Childrens Hosp, Med Ctr, Div Hematol Oncol, Cincinnati, OH 45229 USA

[2] Childrens Hosp, Med Ctr, Div Neurol, Cincinnati, OH 45229 USA

[3] Univ Cincinnati, Med Ctr, Div Biostat, Cincinnati, OH 45267 USA

来源：

JOURNAL OF PEDIATRICS | 2000年 / 137卷 / 05期

关键词：

D O I：

10.1067/mpd.2000.108565

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We report a case of stroke in a child with acquired protein C deficiency receiving valproic acid (VPA). To investigate the possible association of VPA with protein C deficiency, protein C levels were measured in 20 children receiving VPA monotherapy and 20 children receiving other anticonvulsants. Protein C levels were reduced in up to 45% of the VPA-treated subjects.

引用

页码：714 / 718

页数：5

共 12 条

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DALE BM, 1978, LANCET, V1, P1316

[2] THROMBOCYTOPENIA SECONDARY TO HIGH VALPROATE LEVELS IN CHILDREN WITH EPILEPSY [J].