Reprogramming DNA-directed reactions on the basis of a DNA conformational change

被引：46

作者：

Chen, Y ^{[1
]}

Mao, C ^{[1
]}

机构：

[1] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 41期

关键词：

D O I：

10.1021/ja045718j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A strategy has been developed for switching chemical reactions between two identical reagents on the basis of DNA duplex-triplex transition. In response to the change of solution pH, a DNA complex changes its conformation and repositions chemical reagents that are conjugated with DNA strands. As a result, chemical reactions are reprogrammed. This strategy is expected to be applicable to sophisticated chemical syntheses. Copyright © 2004 American Chemical Society.

引用

收藏

页码：13240 / 13241

页数：2

相关论文

共 26 条

[1] Organization of 'nanocrystal molecules' using DNA [J].

Alivisatos, AP ;

Johnsson, KP ;

Peng, XG ;

Wilson, TE ;

Loweth, CJ ;

Bruchez, MP ;

Schultz, PG .

NATURE, 1996, 382 (6592) :609-611

[2]

Calderone CT, 2002, ANGEW CHEM INT EDIT, V41, P4104, DOI 10.1002/1521-3773(20021104)41:21<4104::AID-ANIE4104>3.0.CO

[3]

2-O

[4] An autonomous DNA nanomotor powered by a DNA enzyme [J].

Chen, Y ;

Wang, MS ;

Mao, CD .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2004, 43 (27) :3554-3557

[5] Nucleic acid template-directed assembly of metallosalen-DNA conjugates [J].

Czlapinski, JL ;

Sheppard, TL .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (35) :8618-8619

[6] Highly sensitive in vitro selections for DNA-linked synthetic small molecules with protein binding affinity and specificity [J].

Doyon, JB ;

Snyder, TM ;

Liu, DR .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (41) :12372-12373

[7] Template-directed photoreversible ligation of deoxyoligonucleotides via 5-vinyldeoxyuridine [J].

Fujimoto, K ;

Matsuda, S ;

Takahashi, N ;

Saito, I .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (23) :5646-5647

[8]

Gartner ZJ, 2002, ANGEW CHEM INT EDIT, V41, P1796, DOI 10.1002/1521-3773(20020517)41:10<1796::AID-ANIE1796>3.0.CO

[9]

2-Z

[10] Multistep small-molecule synthesis programmed by DNA templates [J].

Gartner, ZJ ;

Kanan, MW ;

Liu, DR .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (35) :10304-10306