Disseminated intravascular coagulation and purpura fulminans secondary to infection

被引：15

作者：

Faust, SN

Heyderman, RS

Levin, M

机构：

[1] Univ Bristol, Sch Med Sci, Dept Pathol & Microbiol, Bristol BS8 1TH, Avon, England

[2] Univ London Imperial Coll Sci Technol & Med, Sch Med St Marys, Dept Paediat, London W2 1PG, England

来源：

BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY | 2000年 / 13卷 / 02期

关键词：

disseminated intravascular coagulation (DIC); purpura fulminans; pathophysiology; therapy; clinical trials; Gram-negative; meningococcal; tissue factor (TF); tissue factor pathway inhibitor (TFPI); antithrombin (ATIII); thrombomodulin (TM); protein C (PC)/activated protein C (APC); tissue plasminogen activator (tPA);

D O I：

10.1053/beha.2000.0067

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Infection is one of the commonest causes of disseminated intravascular coagulation (DIC). DIC is a complex disorder that results from an imbalance of the pro- and anticoagulant regulatory pathways. This chapter will explain the cellular and molecular basis of the disorder and consider the rationale behind current and experimental treatment strategies.

引用

页码：179 / 197

页数：19

共 145 条

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