Metabolic Control of Autophagy

被引：966

作者：

Galluzzi, Lorenzo ^{[1
,2
,3
,4
]}

Pietrocola, Federico ^{[1
,2
,3
,4
,5
]}

Levine, Beth ^{[6
,7
]}

Kroemer, Guido ^{[1
,2
,3
,4
,8
,9
,10
]}

机构：

[1] Ctr Rech Cordeliers, Equipe Llabellise Ligue Natl Canc 11, F-75006 Paris, France

[2] INSERM, U1138, F-75006 Paris, France

[3] Univ Paris 05, Sorbonne Paris Cite, F-75005 Paris, France

[4] Univ Paris 06, F-75005 Paris, France

[5] Univ Paris 11, F-94805 Villejuif, France

[6] Univ Texas SW Med Ctr Dallas, Dept Microbiol, Dept Internal Med, Ctr Autophagy Res, Dallas, TX 75690 USA

[7] Univ Texas SW Med Ctr Dallas, Howard Hughes Med Inst, Dallas, TX 75390 USA

[8] Hop Europe Georges Pompidou, AP HP, Pole Biol, F-75015 Paris, France

[9] Metabol Platform, F-94805 Villejuif, France

[10] Cell Biol Platform, F-94805 Villejuif, France

来源：

CELL | 2014年 / 159卷 / 06期

基金：

欧洲研究理事会;

关键词：

ACTIVATED PROTEIN-KINASE; EXTENDS LIFE-SPAN; NICOTINAMIDE RIBOSIDE; NEONATAL AUTOPHAGY; CELLULAR-RESPONSE; NUTRIENT STRESS; AMINO-ACIDS; MOUSE MODEL; AMPK; MTOR;

D O I：

10.1016/j.cell.2014.11.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Macroautophagy (herein referred to as autophagy) is an evolutionarily conserved mechanism of adaptation to adverse microenvironmental conditions, including limited nutrient supplies. Several sensors interacting with the autophagic machinery have evolved to detect fluctuations in key metabolic parameters. The signal transduction cascades operating downstream of these sensors are highly interconnected to control a spatially and chronologically coordinated autophagic response that maintains the health and function of individual cells while preserving organismal homeostasis. Here, we discuss the physiological regulation of autophagy by metabolic circuitries, as well as alterations of such control in disease.

引用

页码：1263 / 1276

页数：14

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[2]

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[3]

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